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PML — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TP53
—
PML
(direct interaction, pull down)
Kurki et al., J Cell Sci 2003*
-
IRef Biogrid Interaction:
TP53
—
PML
(physical association, affinity chromatography technology)
Kurki et al., J Cell Sci 2003*
-
IRef Biogrid Interaction:
TP53
—
PML
(physical association, affinity chromatography technology)
Fogal et al., EMBO J 2000*
-
IRef Biogrid Interaction:
TP53
—
PML
(direct interaction, pull down)
Guo et al., Nat Cell Biol 2000*
-
IRef Biogrid Interaction:
TP53
—
PML
(physical association, affinity chromatography technology)
Guo et al., Nat Cell Biol 2000*
-
IRef Biogrid Interaction:
TP53
—
PML
(physical association, affinity chromatography technology)
Insinga et al., EMBO J 2004*
-
IRef Biogrid Interaction:
TP53
—
PML
(direct interaction, enzymatic study)
Chu et al., Oncogene 2011*
-
IRef Biogrid Interaction:
TP53
—
PML
(physical association, affinity chromatography technology)
Li et al., Oncogene 2011*
-
IRef Biogrid Interaction:
TP53
—
PML
(direct interaction, pull down)
Bernassola et al., Oncogene 2005*
-
IRef Biogrid Interaction:
TP53
—
PML
(direct interaction, pull down)
Fogal et al., EMBO J 2000*
-
IRef Hprd Interaction:
TP53
—
PML
(in vitro)
Guo et al., Nat Cell Biol 2000*, Fogal et al., EMBO J 2000*, Pearson et al., Oncogene 2001*
-
IRef Hprd Interaction:
TP53
—
PML
(in vivo)
Guo et al., Nat Cell Biol 2000*, Fogal et al., EMBO J 2000*, Pearson et al., Oncogene 2001*
-
IRef Intact Interaction:
Complex of PML-MDM2-TP53-PML-MDM2-TP53
(direct interaction, anti bait coimmunoprecipitation)
Kurki et al., J Cell Sci 2003*
-
IRef Intact Interaction:
Complex of PML-SIRT1-TP53
(colocalization, imaging technique)
Langley et al., EMBO J 2002*
-
IRef Intact Interaction:
PML
—
TP53
(physical association, anti bait coimmunoprecipitation)
Kurki et al., J Cell Sci 2003*
-
IRef Intact Interaction:
PML
—
TP53
(physical association, anti bait coimmunoprecipitation)
Li et al., Oncogene 2011*
-
IRef Intact Interaction:
PML
—
TP53
(colocalization, confocal microscopy)
Li et al., Oncogene 2011*
-
IRef Ophid Interaction:
PML
—
TP53
(aggregation, confirmational text mining)
Pearson et al., Oncogene 2001*
-
IRef Ophid Interaction:
PML
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Pearson et al., Nature 2000
:
Here we report that the tumour suppressor
PML regulates the
p53 response to oncogenic signals ... We found that oncogenic Ras upregulates PML expression, and overexpression of
PML induces senescence in a
p53 dependent manner
Ferbeyre et al., Genes Dev 2000
:
Like oncogenic ras,
PML increased the levels of p16, hypophosphorylated Rb, phosphoserine-15
p53 , and expression of p53 transcriptional targets
Seker et al., Oncogene 2003
:
Recent findings indicate that
PML regulates the
p53 response to oncogenic signals ... Here, we define a
p53 dependent role for
PML in response to DNA damage
Wei et al., J Biol Chem 2003
(Osteosarcoma) :
PML stimulates
p53 activity by recruiting it to nuclear foci termed PML nuclear bodies
Louria-Hayon et al., J Biol Chem 2003
:
Here we investigated the
role of the
promyelocytic leukemia protein (PML) in the activation of
p53 in response to stress ... We found that
PML is
critical for the accumulation of
p53 in response to DNA damage under physiological conditions ...
PML recruits Chk2 and p53 into the PML nuclear bodies and
enhances p53/Chk2 interaction
Möller et al., Cancer Res 2003
(Osteosarcoma) :
PML is
required for homeodomain interacting protein kinase 2 ( HIPK2 ) -mediated
p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains
Kim et al., Nucleic Acids Res 2003
:
Identification of Daxx interacting with p73, one of the p53 family, and its
regulation of
p53 activity by competitive interaction with
PML
Zhu et al., J Biol Chem 2003
:
In the current study, we investigated whether interaction between MDM2 and
PML can indirectly
affect p53 activity ... Increasing amounts of MDM2 inhibited p53 activation by
PML but could not
inhibit PML mediated activation of a
p53 fusion protein that lacked the MDM2 binding domain
de Stanchina et al., Mol Cell 2004
(Leukemia, Promyelocytic, Acute) :
Hence,
p53 is
required for
PML induction in response to oncogenes and DNA damaging chemotherapeutics
Bernardi et al., Nat Cell Biol 2004
:
PML regulates
p53 stability by sequestering Mdm2 to the nucleolus ... Here, we show that
PML enhances
p53 stability by sequestering Mdm2 to the nucleolus
Bao-Lei et al., J Cell Biochem 2006
(Breast Neoplasms) :
Inhibition of
PML expression
had no detectable effect on the expression of endogenous
p53 at the mRNA level ; however, a significant decrease of p53 protein was observed
Pampin et al., J Virol 2006
:
We describe herein the molecular events following poliovirus infection that lead to
PML dependent
p53 activation and protection against virus infection
Bellodi et al., Cell cycle (Georgetown, Tex.) 2006
(Leukemia, Promyelocytic, Acute) :
Remarkably, Mut
PML inhibits
p53 transcriptional, growth suppressive, and apoptotic functions, thus suggesting that cytoplasmic expression of PML has an impact on survival through inhibition of nuclear PML
Stagno D'Alcontres et al., J Cell Biol 2007
:
Lack of TRF2 in ALT cells causes
PML dependent
p53 activation and loss of telomeric DNA
Alsheich-Bartok et al., Oncogene 2008
:
PML enhances the regulation of
p53 by CK1 in response to DNA damage ... The
promyelocytic leukemia protein (PML) regulates certain modifications of
p53 in response to DNA damage ... We found that
PML enhances Thr18 phosphorylation of endogenous
p53 in response to stress ... Our findings support a
role for
PML in the regulation of
p53 by CK1
Haupt et al., Cancer Res 2009
(Cell Transformation, Neoplastic...) :
Importantly,
PML enhances the transcriptional activity of mutant
p53
Li et al., Oncogene 2011
:
Our finding has thus provided a new avenue for understanding the mechanism by which
PML activates
p53 and exerts its role as a tumor suppressor
Vernier et al., Genes Dev 2011
(Prostatic Hyperplasia) :
Here, we show that the mechanism by which
PML induces a permanent cell cycle exit and
activates p53 and senescence involves a recruitment of E2F transcription factors bound to their promoters and the retinoblastoma ( Rb ) proteins to PML nuclear bodies enriched in heterochromatin proteins and protein phosphatase 1a
Chiantore et al., PloS one 2012
(Cell Transformation, Viral) :
Indeed, experiments in gene silencing via specific siRNAs have shown that
PML is essential in the execution of the senescence programme and that both
p53 and p21 pathways are
involved
Yang et al., Oncogene 2013
:
Doxorubicin, a common chemotherapeutic agent, is known to promote
PML mediated
p53 activation in part by promoting PML dependent MDM2 nucleolar sequestration ... We discovered that BMK1 deactivation coupled with doxorubicin synergistically enhanced MDM2 nucleolar sequestration and, consequently, promoted
PML mediated
p53 upregulation leading to tumor cell apoptosis in vitro and tumor regression in vivo
Papa et al., Genes & cancer 2012
:
It has been shown that PML favors both p53 accumulation and transcriptional activity ; in turn,
PML expression is directly
regulated by
p53 , and this reciprocal regulation contributes to p53 mediated apoptosis and senescence