Gene interactions and pathways from curated databases and text-mining

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PML — TP53

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Pearson et al., Nature 2000 : Here we report that the tumour suppressor PML regulates the p53 response to oncogenic signals ... We found that oncogenic Ras upregulates PML expression, and overexpression of PML induces senescence in a p53 dependent manner
Ferbeyre et al., Genes Dev 2000 : Like oncogenic ras, PML increased the levels of p16, hypophosphorylated Rb, phosphoserine-15 p53 , and expression of p53 transcriptional targets
Seker et al., Oncogene 2003 : Recent findings indicate that PML regulates the p53 response to oncogenic signals ... Here, we define a p53 dependent role for PML in response to DNA damage
Wei et al., J Biol Chem 2003 (Osteosarcoma) : PML stimulates p53 activity by recruiting it to nuclear foci termed PML nuclear bodies
Louria-Hayon et al., J Biol Chem 2003 : Here we investigated the role of the promyelocytic leukemia protein (PML) in the activation of p53 in response to stress ... We found that PML is critical for the accumulation of p53 in response to DNA damage under physiological conditions ... PML recruits Chk2 and p53 into the PML nuclear bodies and enhances p53/Chk2 interaction
Möller et al., Cancer Res 2003 (Osteosarcoma) : PML is required for homeodomain interacting protein kinase 2 ( HIPK2 ) -mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains
Kim et al., Nucleic Acids Res 2003 : Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML
Zhu et al., J Biol Chem 2003 : In the current study, we investigated whether interaction between MDM2 and PML can indirectly affect p53 activity ... Increasing amounts of MDM2 inhibited p53 activation by PML but could not inhibit PML mediated activation of a p53 fusion protein that lacked the MDM2 binding domain
de Stanchina et al., Mol Cell 2004 (Leukemia, Promyelocytic, Acute) : Hence, p53 is required for PML induction in response to oncogenes and DNA damaging chemotherapeutics
Bernardi et al., Nat Cell Biol 2004 : PML regulates p53 stability by sequestering Mdm2 to the nucleolus ... Here, we show that PML enhances p53 stability by sequestering Mdm2 to the nucleolus
Bao-Lei et al., J Cell Biochem 2006 (Breast Neoplasms) : Inhibition of PML expression had no detectable effect on the expression of endogenous p53 at the mRNA level ; however, a significant decrease of p53 protein was observed
Pampin et al., J Virol 2006 : We describe herein the molecular events following poliovirus infection that lead to PML dependent p53 activation and protection against virus infection
Bellodi et al., Cell cycle (Georgetown, Tex.) 2006 (Leukemia, Promyelocytic, Acute) : Remarkably, Mut PML inhibits p53 transcriptional, growth suppressive, and apoptotic functions, thus suggesting that cytoplasmic expression of PML has an impact on survival through inhibition of nuclear PML
Stagno D'Alcontres et al., J Cell Biol 2007 : Lack of TRF2 in ALT cells causes PML dependent p53 activation and loss of telomeric DNA
Alsheich-Bartok et al., Oncogene 2008 : PML enhances the regulation of p53 by CK1 in response to DNA damage ... The promyelocytic leukemia protein (PML) regulates certain modifications of p53 in response to DNA damage ... We found that PML enhances Thr18 phosphorylation of endogenous p53 in response to stress ... Our findings support a role for PML in the regulation of p53 by CK1
Haupt et al., Cancer Res 2009 (Cell Transformation, Neoplastic...) : Importantly, PML enhances the transcriptional activity of mutant p53
Li et al., Oncogene 2011 : Our finding has thus provided a new avenue for understanding the mechanism by which PML activates p53 and exerts its role as a tumor suppressor
Vernier et al., Genes Dev 2011 (Prostatic Hyperplasia) : Here, we show that the mechanism by which PML induces a permanent cell cycle exit and activates p53 and senescence involves a recruitment of E2F transcription factors bound to their promoters and the retinoblastoma ( Rb ) proteins to PML nuclear bodies enriched in heterochromatin proteins and protein phosphatase 1a
Chiantore et al., PloS one 2012 (Cell Transformation, Viral) : Indeed, experiments in gene silencing via specific siRNAs have shown that PML is essential in the execution of the senescence programme and that both p53 and p21 pathways are involved
Yang et al., Oncogene 2013 : Doxorubicin, a common chemotherapeutic agent, is known to promote PML mediated p53 activation in part by promoting PML dependent MDM2 nucleolar sequestration ... We discovered that BMK1 deactivation coupled with doxorubicin synergistically enhanced MDM2 nucleolar sequestration and, consequently, promoted PML mediated p53 upregulation leading to tumor cell apoptosis in vitro and tumor regression in vivo
Papa et al., Genes & cancer 2012 : It has been shown that PML favors both p53 accumulation and transcriptional activity ; in turn, PML expression is directly regulated by p53 , and this reciprocal regulation contributes to p53 mediated apoptosis and senescence