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BTK — TLR2

Pathways - manually collected, often from reviews:

• Reactome Reaction: BTK → TLR2 (indirect_complex) Jefferies et al., J Biol Chem 2003, Brunner et al., Histol Histopathol 2005, Gray et al., J Biol Chem 2006, Piao et al., J Biol Chem 2008, Lee et al., Proc Natl Acad Sci U S A 2012
• Reactome Reaction: BTK → TLR2 (reaction) Li et al., Proc Natl Acad Sci U S A 2002, Jefferies et al., J Biol Chem 2003, Kollewe et al., J Biol Chem 2004, Brunner et al., Histol Histopathol 2005, Gray et al., J Biol Chem 2006, Cheng et al., Biochem Biophys Res Commun 2007, Kawagoe et al., J Exp Med 2007, Piao et al., J Biol Chem 2008, Kawagoe et al., Nat Immunol 2008, Lee et al., Proc Natl Acad Sci U S A 2012

Text-mined interactions from Literome

Horwood et al., J Immunol 2006 : These data provide evidence for a common requirement for Btk in TLR2- and TLR4 mediated induction of two important proinflammatory cytokines, TNF and IL-1beta, and reveal important differences in the TLR mediated signals required for the production of IL-6, IL-8, and IL-10
Schmidt et al., J Immunol 2006 : Recent evidence has also supported a role for Btk in TLR signaling
Jyonouchi et al., Eur J Pediatr 2008 (Deafness...) : Moreover, BTK null cells from these patients exhibited robust responses to TLR agonists, normal natural killer ( NK ) cell activity, and normal pDC functions.CONCLUSION : Our results do not indicate the essential role of Btk in TLR signaling and DC development
Taneichi et al., Clin Immunol 2008 (Agammaglobulinemia...) : These findings suggest that BTK may thus be required for TLR signaling in DCs
Marron et al., Clin Immunol 2010 (Agammaglobulinemia...) : Bruton's tyrosine kinase (Btk) has been reported to mediate signaling through toll-like receptors ( TLRs ) in many cell types, however, the role of Btk in TLR activation of neutrophils remains unclear
Liu et al., Nat Immunol 2011 (Sepsis) : Then, Btk interacted with the adaptor molecules MyD88 and TRIF and thereby promoted TLR signaling