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PPARD — RELA
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Rival et al., Eur J Pharmacol 2002
:
PPARalpha and
PPARdelta activators
inhibit cytokine induced nuclear translocation of
NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells
Planavila et al., Cardiovasc Res 2005
(Cardiomegaly) :
Finally, coimmunoprecipitation studies showed that L-165041 strongly enhanced the physical interaction between PPARbeta/delta and the p65 subunit of NF-kappaB, suggesting that increased association between these two proteins is the mechanism responsible for antagonizing
NF-kappaB activation by
PPARbeta/delta activators ... These results suggest that
PPARbeta/delta activation
inhibits PE-induced cardiac hypertrophy and LPS induced
NF-kappaB activation
Planavila et al., J Biol Chem 2005
(Hypertrophy) :
Lipopolysaccharide stimulation of
NF-kappaB in embryonic rat heart derived H9c2 myotubes, which only express PPARbeta/delta,
caused both a reduction in Pdk4 expression and DNA binding activity of
PPARbeta/delta to its response element, effects that were reversed by NF-kappaB inhibitors ... In hypertrophied hearts of banded rats the reduction in the expression of Pdk4 was accompanied by activation of
NF-kappaB and
enhanced interaction between p65 and
PPARbeta/delta
Aarenstrup et al., J Invest Dermatol 2008
:
In this article we further investigate the molecular mechanisms dictating the
NF-kappaB dependent repression of
PPARdelta in human keratinocytes
RodrÃguez-Calvo et al., Diabetes 2008
:
Because mitogen activated protein kinase-extracellular signal related kinase ( ERK ) 1/2 ( MEK1/2 ) is involved in LPS induced NF-kappaB activation in adipocytes, we explored whether
PPARbeta/delta prevented
NF-kappaB activation by inhibiting this pathway