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EGF — RB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RB1 → EGF (increases) Amrani et al., Am J Physiol Lung Cell Mol Physiol 2003*
  Evidence: In addition, IFN-gamma decreased activation of cdk2 and expression of cyclin E, upstream signaling molecules responsible for Rb hyperphosphorylation in the late G1 phase.

Text-mined interactions from Literome

Franch et al., J Cell Biol 1995 (Hypertrophy) : EGF alone increased the amount of hyperphosphorylated ( inactive ) pRB ; TGF beta blocked EGF induced pRB phosphorylation, maintaining pRB in the active form
Tovbin et al., Proc Assoc Am Physicians 1997 (Hyperplasia...) : TGF-beta converts EGF induced hyperplasia to hypertrophy and inhibits EGF induced pRB phosphorylation