Gene interactions and pathways from curated databases and text-mining

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IGF1R — IRS1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Boney et al., Mol Endocrinol 2000 : IGF-I induces signaling pathways that involve IGF-I receptor mediated tyrosine phosphorylation of Shc and insulin receptor substrate 1 (IRS-1)
Allard et al., American journal of physiology. Renal physiology 2007 (Albuminuria...) : The early phase of diabetes was found to be associated with an increase in glomerular expression of IGF1-R , PDGF-R, and TGF-beta-RII and activation of IRS1 , Erk 1/2, and Smad 2/3
Leclerc et al., Journal of molecular signaling 2010 : Inhibition of IGF-1R signaling using the tyrosine kinase inhibitor HNMPA ( AM ) 3 resulted in significant decrease in P-IRS-1 ( Ser794 ) and P-Akt ( Thr308 )
Xuan et al., J Biol Chem 2010 (Diabetes Mellitus...) : To examine genetically the involvement of Irs1 and Irs2 in Igf1r signaling, we generated double mutant mice lacking Igf1r specifically in pancreatic ß cells in an Irs1- or Irs2-null background
Sun et al., Endocrinology 2011 : No alterations were observed in downstream signaling targets of prolactin and progesterone, suggesting that activation of the IGF-1R may directly regulate expression of IRS-1/2 during alveolar development and differentiation
Xie et al., Cancer cell international 2013 : Klotho is a tumor suppressor in gastric cancer, which regulates IGF-1R phosphorylation and the subsequent activation of IRS-1/PI3K/Akt/mTOR signaling, tumor cell proliferation, apoptosis, and autophagy
Myers et al., Endocrinology 1993 : The insulin-like growth factor-I (IGF-I) receptor also mediated the tyrosine phosphorylation of IRS-1 and increased the amount of PtdIns 3'-kinase activity bound to IRS-1 in Chinese hamster ovary cells
Takahashi et al., Endocrinology 1997 : Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts