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CXCL1 — IFNG
Text-mined interactions from Literome
Hardaker et al., FASEB J 2004
(Inflammation...) :
In primary cultured hASM cells taken from normal donors,
CXCL10 protein expression was
induced by
IFN-gamma and TNF-alpha, cytokines reported as elevated in COPD, and a synergistic response was obtained when they were combined
Hillyer et al., Clin Exp Immunol 2003
:
In combination with TNF-alpha,
IFN-gamma suppressed
CXCL8 but enhanced CCL5 and CXCL10, whereas transforming growth factor ( TGF ) -beta reduced secretion of all chemokines
Thomas et al., J Immunol 2004
(Bronchial Hyperreactivity) :
In lymphocytes restimulated with CXCL9 and allergen in vitro,
CXCL9 down-regulated IL-4 expression and up-regulated
IFN-gamma expression, suggesting that CXCL9 is able to direct activated lymphocytes toward a Th1-type phenotype
Omari et al., Brain 2005
(Hypertrophy...) :
CXCL8 and
CXCL1 production by human astrocytes at both the RNA and protein levels could be
induced by interleukin (IL)-1beta, while CXCL10 was induced by both IL-1beta and
interferon-gamma
Traidl-Hoffmann et al., Int Arch Allergy Immunol 2006
:
Keratinocyte cultures established from normal skin of healthy donors were
activated by
IFN-gamma in the absence or presence of desloratadine and loratadine, and tested for the release of CCL5/RANTES,
CXCL8/IL-8 , CCL17/TARC and CXCL10/IP-10 ... Desloratadine and loratadine inhibited the constitutive and
IFN-gamma induced release of CCL5,
CXCL8 and CXCL10 from keratinocytes, while the low release of CCL17 remained unchanged
Bandyopadhyay et al., Biochem Pharmacol 2006
:
In addition, apigenin inhibits
IFNgamma stimulated secretion of monokines,
CXCL-9 , and -10 in MC3T3-E1 cells
Kanda et al., Endocrinology 2007
(MAP Kinase Signaling System...) :
Prolactin enhances
interferon-gamma induced production of CXC ligand 9 (CXCL9),
CXCL10 , and CXCL11 in human keratinocytes ... Although prolactin alone was ineffective, it enhanced
IFN-gamma induced secretion and mRNA expression of CXCL9,
CXCL10 , and CXCL11 in parallel to the activation of STAT1, NF-kappaB, and IRF-1 ... These results suggest that prolactin may enhance
IFN-gamma induced CXCL9,
CXCL10 , and CXCL11 production in keratinocytes via activation of STAT1, NF-kappaB, and IRF-1 through JAK2 and MEK/ERK pathways
Kanda et al., Eur J Immunol 2007
:
IL-18 enhances
IFN-gamma induced production of CXCL9,
CXCL10 , and CXCL11 in human keratinocytes ... We examined the in vitro effects of IL-18 on
IFN-gamma induced CXCL9,
CXCL10 , and CXCL11 production in human keratinocytes ... IL-18 enhanced the
IFN-gamma induced secretion and mRNA expression of CXCL9,
CXCL10 , and CXCL11 in parallel to the activation of NF-kappaB, STAT1, and IFN-regulatory factor (IRF)-1 ... These results suggest that IL-18 may potentiate
IFN-gamma induced CXCL9,
CXCL10 , and CXCL11 production in keratinocytes by activating NF-kappaB, STAT1, or IRF-1 through PI3 K/Akt and MEK/ERK pathways
Taubert et al., Vet Res Commun 2008
:
Furthermore,
IFNgamma-stimulation led to a strong upregulation in the transcription of VCAM-1, ICAM-1, CXCL10 and CCL2 genes and to a low to moderate increase in the E- and P-selectin, CXCL1,
CXCL8 , CCL5, COX-2 and iNOS gene transcripts, but failed to enhance GM-CSF gene transcription ... Furthermore,
IFNgamma-stimulation led to a strong upregulation in the transcription of VCAM-1, ICAM-1, CXCL10 and CCL2 genes and to a low to moderate increase in the E- and P-selectin,
CXCL1 , CXCL8, CCL5, COX-2 and iNOS gene transcripts, but failed to enhance GM-CSF gene transcription
Xu et al., Stem Cells 2009
:
C/EBPbeta knockdown also inhibited the synergistic expression of
CXCL1 , inducible nitric oxide synthase, and CCL5 in
response to concomitant
IFNgamma and TNFalpha ... Furthermore, while STAT1 is critical in IFNgamma signaling, we found that STAT1 knockdown in MSCs did not affect C/EBPbeta expression or the synergistic
induction of IL-6 and
CXCL1 by
IFNgamma and TNFalpha
Milks et al., Liver Int 2009
(Disease Models, Animal...) :
Ifng is dichotomous in the regulation of distinct chemokine subfamilies : specifically,
Ifng is
critical for overexpression of specific
CXCL genes but dispensable for overexpression of specific CCL genes