Gene interactions and pathways from curated databases and text-mining

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LITAF — TNF

Text-mined interactions from Literome

Myokai et al., Proc Natl Acad Sci U S A 1999 : Inhibition of LITAF mRNA expression in THP-1 cells resulted in a reduction of TNF-alpha transcripts ... Together, these findings suggest that LITAF plays an important role in the activation of the human TNF-alpha gene and proposes a new mechanism to control TNF-alpha gene expression
Bolcato-Bellemin et al., J Endotoxin Res 2004 (Inflammation) : Taken together, these results highlight the important role of LITAF in the regulation of TNF-alpha gene expression and suggest a potential role of LITAF in mouse organogenesis
Hong et al., Dev Comp Immunol 2006 (Coccidiosis) : We conclude that chicken LITAF may play an important role in the regulation of TNF-alpha gene expression during the course of coccidiosis or tumorigenesis
Stucchi et al., Inflamm Bowel Dis 2006 (Colitis, Ulcerative...) : These data provide strong evidence of a role for LITAF in the pathophysiological regulation of the TNF-alpha gene and underscore the potential value of anti-LITAF strategies in the clinical management of these diseases
Huang et al., Biochem Biophys Res Commun 2008 : Lipopolysaccharide induced TNF-alpha factor ( LITAF ), a transcription factor, can regulate tumor necrosis factor alpha (TNF-alpha) transcription
Bushell et al., PloS one 2011 (Inflammation) : This study provides evidence that LITAF contributes to the regulation of TNF-a in LPM harvested following acute inflammation or LPS treatment paving the way for future work focusing on LITAF inhibitors in the treatment of TNF-a mediated inflammatory conditions
Bertolo et al., Br J Haematol 2013 (Lymphoma, B-Cell) : Gain- and loss-of-function experiments in different B-cell lymphoma cell lines revealed that, in contrast to its function in monocytes, LITAF does not induce lipopolysaccharide mediated TNF secretion in B cells