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LITAF — TNF
Text-mined interactions from Literome
Myokai et al., Proc Natl Acad Sci U S A 1999
:
Inhibition of
LITAF mRNA expression in THP-1 cells
resulted in a reduction of
TNF-alpha transcripts ... Together, these findings suggest that
LITAF plays an important role in the activation of the human
TNF-alpha gene and proposes a new mechanism to control TNF-alpha gene expression
Bolcato-Bellemin et al., J Endotoxin Res 2004
(Inflammation) :
Taken together, these results highlight the important
role of
LITAF in the regulation of
TNF-alpha gene expression and suggest a potential role of LITAF in mouse organogenesis
Hong et al., Dev Comp Immunol 2006
(Coccidiosis) :
We conclude that chicken
LITAF may
play an important role in the regulation of
TNF-alpha gene expression during the course of coccidiosis or tumorigenesis
Stucchi et al., Inflamm Bowel Dis 2006
(Colitis, Ulcerative...) :
These data provide strong evidence of a
role for
LITAF in the pathophysiological regulation of the
TNF-alpha gene and underscore the potential value of anti-LITAF strategies in the clinical management of these diseases
Huang et al., Biochem Biophys Res Commun 2008
:
Lipopolysaccharide induced TNF-alpha factor (
LITAF ), a transcription factor, can
regulate tumor necrosis factor alpha (TNF-alpha) transcription
Bushell et al., PloS one 2011
(Inflammation) :
This study provides evidence that
LITAF contributes to the regulation of
TNF-a in LPM harvested following acute inflammation or LPS treatment paving the way for future work focusing on LITAF inhibitors in the treatment of TNF-a mediated inflammatory conditions
Bertolo et al., Br J Haematol 2013
(Lymphoma, B-Cell) :
Gain- and loss-of-function experiments in different B-cell lymphoma cell lines revealed that, in contrast to its function in monocytes,
LITAF does not
induce lipopolysaccharide mediated
TNF secretion in B cells