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PLD1 — SYK
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hitomi et al., FEBS Lett 1999
:
Cross linking of the B cell receptor
induces activation of
phospholipase D through
Syk , Btk and phospholipase C-gamma2 ... These results demonstrate that
Syk , Btk and PLC-gamma2 are
essential for BCR induced
PLD activation
Hitomi et al., Blood 2004
:
However, FcepsilonRI induced
PLD activation
required Syk and was downstream of the Ca ( 2+ ) response, suggesting that basal PLD1 activity rather than that activated by cell stimulation controlled these early signaling events