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BACH1 — HMOX1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: HMOX1 → BACH1 (directlyDecreases, HMOX1 Activity)
  Evidence: Therefore, Bach1 functions as a hypoxia-inducible repressor for the HO-1 gene, thereby contributing to fine-tuning of oxygen homeostasis in human cells.

Text-mined interactions from Literome

Ferrando-Miguel et al., J Neural Transm Suppl 2003 (Down Syndrome) : Increased BACH1 , however, did not lead to decreased HO1 , which would have explained oxidative stress observed in fetal DS
Suzuki et al., EMBO J 2004 : Bach1 is a transcriptional repressor of heme oxygenase-1 and beta-globin genes, both of which are known to be transcriptionally induced by heme
Shan et al., J Biol Chem 2004 : Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells : insights from studies with small interfering RNAS
Omura et al., Genes Cells 2005 (Arteriosclerosis) : These results indicate that Bach1 plays a critical role in the regulation of HO-1 expression, macrophage function, SMC proliferation and neointimal formation
Yamasaki et al., J Biochem 2005 : The repression of HO-1 reporter activity by Bach1 was attenuated by co-transfecting IHABP in a dose dependent manner
Ghaziani et al., J Hepatol 2006 (Carcinoma, Hepatocellular...) : Other recent work has implicated Bach1 , a heme binding protein that represses gene expression, in the regulation of HO-1 gene expression
Ozono et al., Curr Pharm Biotechnol 2006 : Bach1 normally represses HO-1 expression
Shan et al., FASEB J 2006 : Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin
Reichard et al., Nucleic Acids Res 2007 : Here, we describe the dynamic roles of BACH1 and NRF2 in the transcription of the heme oxygenase-1 (HMOX1) gene
Sakoda et al., Neurosci Lett 2008 : Regulation of heme oxygenase-1 by transcription factor Bach1 in the mouse brain ... Bach1 is a transcriptional repressor of the HO-1 gene, and plays a critical role in tissue protection from oxidative stress by reperfusion injury of the myocardium ... In this study, we examined the role of Bach1 in HO-1 regulation of the various brain sites by investigating the expression of Bach1 and HO-1 in brain tissues of mice bearing Bach1-deficient ( Bach1 ( -/- ) ) or wild-type ( Bach1 ( +/+ ) ) genes
Kanno et al., J Neurotrauma 2009 (Lameness, Animal...) : Bach1 is a transcriptional repressor of the HO-1 gene ( Hmox-1 ) ... In the present study, we examined whether Bach1 deficiency increases HO-1 expression and reduces neural tissue damage in a spinal cord injury model using Bach1 knock-out ( KO ) mice and wild-type ( WT ) mice
Iida et al., Tohoku J Exp Med 2009 (Edema) : Bach1-deficiency in mice leads to higher expression of Hmox-1 in various tissues
Tanimoto et al., Free Radic Biol Med 2009 (Hyperoxia) : Bach1 is a transcriptional repressor of the heme oxygenase (HO)-1 gene
Hou et al., Hepatology 2010 (Carcinoma, Hepatocellular...) : Bach1 , a basic leucine zipper mammalian transcriptional repressor, negatively regulates heme oxygenase 1 (HMOX1) , a key cytoprotective enzyme that has antioxidant and anti-inflammatory activities
Miyazaki et al., Cancer Sci 2010 (Leukemia, Myeloid, Acute) : Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1 ... The downregulation of the HO-1 gene with siRNA increased a cytotoxic effect of an anticancer drug on primary AML cells, whereas the downregulation of Bach1 increased HO-1 expression, leading to enhanced survival
Watanabe-Matsui et al., Blood 2011 : Heme oxygenase-1 , which is known to be regulated by heme, was repressed by both Bach2 and Bach1 in B cells
Raval et al., Free Radic Biol Med 2012 : The role of Bach1 in ultraviolet A-mediated human heme oxygenase 1 regulation in human skin fibroblasts ... The mechanism underlying Bach1 mediated HO-1 repression is less well understood although cellular localization seems to be crucial ... Overexpression of Bach1 , together with MafK, represses basal and UVA mediated HO-1 protein expression, whereas silencing of the Bach1 gene by Bach1-specific siRNAs causes robust enhancement of constitutive HO-1 levels