Gene interactions and pathways from curated databases and text-mining

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IL1B — IL2RG

Text-mined interactions from Literome

Wang et al., Fish Shellfish Immunol 2001 : Low levels of gammaC transcript were detectable in unstimulated macrophage cultures and expression was increased by stimulation of the cells with recombinant trout interleukin-1beta (IL-1beta) or LPS ... Similarly, in the RTG cell line which exhibited even lower level constitutive expression, stimulation with IL-1beta increased gammaC transcript levels but LPS had no effect
Panzer et al., Clin Exp Immunol 1993 : We show in this system that exogenously added IL-1 beta , IL-6 and TNF-alpha induces IL-2 receptor (R) up-regulation and IL-2 production, and proliferation by both CD4+ and CD8+ cells
Sumiyoshi et al., J Gastroenterol 1997 (Pancreatic Neoplasms) : The secretion of C4 and factor B in ductal cell lines ( PANC-1 and MIA PaCa-2 ) was independently regulated by interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma ; C4 secretion was induced by IFN-gamma, whereas factor B secretion was induced by IL-1 beta , TNF-alpha, or IFN-gamma
Bonder et al., J Immunol 1998 : Studies with Abs to gammac and an IL-4 mutant that is unable to bind to gammac showed that IL-4 can suppress IL-1beta but not TNF-alpha production by LPS stimulated monocytes in the presence of little or no functioning gammac