◀ Back to IL1B

IL1B — IL1R1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of IL1R1-IL1RAP → IL1B (increases) Huang et al., Proc Natl Acad Sci U S A 1997*
  Evidence: Here we describe the function of a previously identified IL-1 receptor subunit designated IL-1 receptor accessory protein (IL-1RAcP). IL-1 treatment of cells induces the formation of a complex containing both IL-1RI and IL-1RAcP. IRAK is recruited to this complex through its association with IL-1RAcP.
• OpenBEL Selventa BEL large corpus: IL1R1 → IL1B (directlyIncreases, IL1B Activity)
  Evidence: Furthermore, IL-18R at least partly shares the signal transducing system with IL-1R. Thus, the IL-18-IL-18R system has a striking similarity to the IL-1-IL-1R system. From entrez gene summary of IL1R1: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induce...
• BioCarta signal transduction through il1r: IRAKs (IRAK3/IRAK1/IRAK2) → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: TOLLIP → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: MYD88 → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1RAcP (IL1RAP) (modification, collaborate)
• BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1-beta (IL1B) (modification, collaborate)
• BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1R (IL1R1) (modification, collaborate)
• BioCarta signal transduction through il1r: IL-1-beta (IL1B) → IL-1R (IL1R1) (modification, collaborate)
• KEGG Apoptosis: IL1A/IL1B → IL1R1/IL1RAP (protein-protein, activation)
• KEGG Osteoclast differentiation: IL1A/IL1B → IL1R1 (protein-protein, activation)
• KEGG MAPK signaling pathway: IL1A/IL1B → IL1R1/IL1R2 (protein-protein, activation)
• KEGG Amoebiasis: IL1B → IL1R1/IL1R2 (protein-protein, activation)
• KEGG Cytokine-cytokine receptor interaction: IL1B → Complex of IL1R1-IL1RAP (protein-protein, activation)
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IRAK4 (IRAK4) (modification, collaborate) Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IL1 beta fragment/IL1R1/IL1RAP/MYD88 complex (IL1B-IL1R1-IL1RAP-MYD88) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK4 (IRAK4) → IL1 beta fragment/IL1R1/IL1RAP/MYD88s complex (IL1B-IL1R1-IL1RAP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK4 (IRAK4) → IL1 beta fragment/IL1R1/IL1RAP/MYD88 complex (IL1B-IL1R1-IL1RAP-MYD88) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88s complex (IL1B-IL1R1-IL1RAP) → IL1 beta fragment/IL1R1/IL1RAP/MYD88 complex (IL1B-IL1R1-IL1RAP-MYD88) (modification, inhibits)
  Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: MYD88 (MYD88) → IL1 beta fragment/IL1R1/IL1RAP complex (IL1B-IL1R1-IL1RAP) (modification, collaborate)
  Muzio et al., Science 1997, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: MYD88 (MYD88) → IL1 beta fragment/IL1R1/IL1RAP/MYD88 complex (IL1B-IL1R1-IL1RAP-MYD88) (modification, collaborate)
  Muzio et al., Science 1997, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP complex (IL1B-IL1R1-IL1RAP) → IL1 beta fragment/IL1R1/IL1RAP/MYD88 complex (IL1B-IL1R1-IL1RAP-MYD88) (modification, collaborate)
  Muzio et al., Science 1997, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1RAP (IL1RAP) → IL1 beta fragment/IL1R1/IL1RAP complex (IL1B-IL1R1-IL1RAP) (modification, collaborate)
  Labriola-Tompkins et al., Proc Natl Acad Sci U S A 1991*, Greenfeder et al., J Biol Chem 1995*
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1R1 (IL1R1) → IL1 beta fragment (IL1B) (modification, collaborate) Labriola-Tompkins et al., Proc Natl Acad Sci U S A 1991*, Greenfeder et al., J Biol Chem 1995*
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1R1 (IL1R1) → IL1 beta fragment/IL1R1/IL1RAP complex (IL1B-IL1R1-IL1RAP) (modification, collaborate)
  Labriola-Tompkins et al., Proc Natl Acad Sci U S A 1991*, Greenfeder et al., J Biol Chem 1995*
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment (IL1B) → IL1 beta fragment/IL1R1/IL1RAP complex (IL1B-IL1R1-IL1RAP) (modification, collaborate)
  Labriola-Tompkins et al., Proc Natl Acad Sci U S A 1991*, Greenfeder et al., J Biol Chem 1995*
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP complex (IL1B-IL1R1-IL1RAP) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Sizemore et al., Mol Cell Biol 1999, Reddy et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP complex (IL1B-IL1R1-IL1RAP) → IL1 beta fragment/IL1R1/IL1RAP/PI3K complex (IL1B-IL1R1-IL1RAP-PIK3CA-PIK3R1) (modification, collaborate)
  Sizemore et al., Mol Cell Biol 1999, Reddy et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL1-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL1 beta fragment/IL1R1/IL1RAP/PI3K complex (IL1B-IL1R1-IL1RAP-PIK3CA-PIK3R1) (modification, collaborate)
  Sizemore et al., Mol Cell Biol 1999, Reddy et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL1-mediated signaling events: RelA (RELA) → IL1 beta fragment/IL1R1/IL1RAP/PI3K complex (IL1B-IL1R1-IL1RAP-PIK3CA-PIK3R1) (modification, collaborate)
  Sizemore et al., Mol Cell Biol 1999, Reddy et al., J Biol Chem 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: NF kappa B1 p50 (NFKB1) → IL1 beta fragment/IL1R1/IL1RAP/PI3K complex (IL1B-IL1R1-IL1RAP-PIK3CA-PIK3R1) (modification, collaborate)
  Sizemore et al., Mol Cell Biol 1999, Reddy et al., J Biol Chem 1997
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IRAK/TOLLIP complex (IRAK1-TOLLIP) (modification, collaborate)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IRAKM (IRAK3) (modification, collaborate) Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, collaborate)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IRAK/TOLLIP complex (IRAK1-TOLLIP) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, collaborate)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IRAKM (IRAK3) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, inhibits)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → TRAF6 (TRAF6) (modification, collaborate) Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6 complex (IRAK1-TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) (modification, collaborate)
  Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, activates)
  Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) → IRAK (IRAK1) (modification, activates) Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: IL1B → IL1R1 (reaction) Li et al., Proc Natl Acad Sci U S A 2002, Kollewe et al., J Biol Chem 2004, Sims et al., Proc Natl Acad Sci U S A 1993*
• Reactome Reaction: IL1B → IL1R1 (direct_complex) Sims et al., Proc Natl Acad Sci U S A 1993*
• WikiPathways IL1 and megakaryocytes in obesity: IL1B → IL1R1 (activation)
• WikiPathways Monoamine Transport: IL1R1 → IL1B (inhibition) Zhu et al., Biol Psychiatry 2006*
• WikiPathways Serotonin Transporter Activity: IL1B → IL1R1 (mim-binding)
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): IL1B → IL1R1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: IL1R1 — IL1B Vigers et al., Nature 1997*
• IRef Bind_translation Interaction: IL1R1 — IL1B (x-ray crystallography) Vigers et al., Nature 1997*
• IRef Biogrid Interaction: IL1R1 — IL1B (direct interaction, pull down) Symons et al., Proc Natl Acad Sci U S A 1995*
• IRef Dip Interaction: IL1R1 — IL1B (direct interaction, x-ray crystallography) Vigers et al., Nature 1997*
• IRef Hprd Interaction: IL1R1 — IL1B (in vitro) Vigers et al., Nature 1997*
• IRef Innatedb Interaction: IL1R1 — IL1B (unknown, -) Svenson et al., Cytokine 1993*
• IRef Intact Interaction: IL1R1 — IL1B (direct interaction, x-ray crystallography) Vigers et al., Nature 1997*
• IRef Intact Interaction: Complex of IL1RAP-IL1B-IL1B-IL1RAP-IL1R1-IL1R1-IL1R1-IL1B-IL1RAP (physical association, surface plasmon resonance) Wang et al., Nat Immunol 2010*
• IRef Ophid Interaction: IL1R1 — IL1B (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: IL1R1 — IL1B (aggregation, confirmational text mining) Vigers et al., Nature 1997*

Text-mined interactions from Literome

Nalivaeva et al., Cytokine 2000 : Activation of neutral sphingomyelinase by IL-1beta requires the type 1 interleukin 1 receptor
Parker et al., Brain Res Mol Brain Res 2000 : IL-1beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat
Palmer et al., Ann Rheum Dis 2004 : In chondrocytes, IFNbeta alone had no effect, but dose dependently enhanced the secretion of IL1Ra induced by IL1beta ... In addition, IFNbeta enhanced the stimulatory effect of IL1beta on IL1Ra production ... In synovial cell lysates, IFNbeta and IL1beta also increased IL1Ra levels
Shu et al., Respir Physiol Neurobiol 2007 : Taking together, the present study elucidates that PC12 cells bear interleukin-1 receptor and response to IL-1beta stimulation
Cardell et al., Pulm Pharmacol Ther 2008 : To summarize, presence of IL-1beta increases the expression of IL-1 R1 and TNF RI and induces expression of TNF RII in the airway wall
Turnquist et al., J Immunol 2008 : Interestingly, IL-1beta production promotes overexpression of the transmembrane form of the IL-1R family member, IL-1R-like 1, also know as ST2 on RAPA conditioned DC ( RAPA-DC )
Bellehumeur et al., Hum Reprod 2009 : Regulation of IL1R1 and IL1RA by IL1B involved gene transcription activation and that of IL1R2 involved mRNA stabilization
Böni-Schnetzler et al., Endocrinology 2009 : FFA induced IL-1beta and KC expression in mouse islets was completely dependent on the IL-1R/Toll-like receptor ( TLR ) docking protein Myd88 and partly dependent on TLR2 and -4
Seo et al., Biol Reprod 2012 : Collectively, the results indicated that IL1B regulates expression of IL1R1 and IL1RAP and stimulates expression of PTGS1 and PTGS2 that are considered to be the most rate limiting enzymes for endometrial synthesis of PGs during the peri-implantation period of pregnancy in pigs
Bourdiec et al., Am J Reprod Immunol 2013 : IL1B up-regulated both the signaling IL1R1 and the inhibitory IL1R2, while adding hCG further increased IL1R1 and significantly downregulated IL1R2
Bruserud et al., Eur J Haematol 1996 (Acute-Phase Reaction...) : IL1 alpha and IL1 beta caused a similar increase in AML blast release of IL1RA , and addition of anti-IL1 antibodies decreased IL1RA release
Kanda-Nakamura et al., J Periodontol 1996 (Gingivitis...) : We investigated the expression of interleukin-1 receptors (IL-1R) on the surfaces of cultured gingival fibroblasts derived from healthy and inflamed gingiva and the effects of IL-1 alpha and IL-1 beta and prostaglandin E2 ( PGE2 ) on IL-1R expression
Huang et al., Biol Reprod 1997 : Interleukin 1 beta regulates Vero cell interleukin-1 receptor type I messenger ribonucleic acid expression ... To determine the effect of IL-1 beta on IL-1R tI mRNA expression in Vero cells, quantitative competitive PCR methodology was developed
Martel-Pelletier et al., J Rheumatol 1998 (Osteoarthritis) : Diacerhein and rhein can effectively inhibit the synthesis of IL-1beta on human OA synovium, as well as the action of this cytokine at the cartilage level, by reducing the number of chondrocyte IL-1R