Kim et al., J Neurol Sci 2004
(Intracranial Thrombosis) :
We analyzed the effects of MM-LDL on brain capillary endothelial expression of plasminogen activator inhibitor-1 ( PAI-1 ), tissue-type plasminogen activator (tPA), and thrombomodulin (TM) Kim et al., Am J Physiol Heart Circ Physiol 2012
:
p66shc mediates LDL stimulated increase in expression of endothelial intercellular adhesion molecule-1 ( ICAM1 ) and decrease in expression of thrombomodulin (TM) Kumar et al., Arterioscler Thromb Vasc Biol 2013
(Atherosclerosis...) :
Knockdown of myocyte enhancing factor-2, or mutation of the myocyte enhancing factor-2 site in the KLF2 promoter, abrogates LDL induced downregulation of endothelial KLF2 and thrombomodulin , and KLF2 promoter activity ... Similarly, knockdown of enhancer of zeste homolog 2 negates LDL induced downregulation of KLF2 and thrombomodulin in endothelial cells