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APOB — HSPA5

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HSPA5 — APOB (physical association, affinity chromatography technology) Rutledge et al., Arterioscler Thromb Vasc Biol 2009*
• IRef Hprd Interaction: HSPA5 — APOB (in vivo) Zhang et al., J Biol Chem 2003*
• IRef Hprd Interaction: HSPA5 — APOB (in vitro) Zhang et al., J Biol Chem 2003*
• IRef Intact Interaction: Complex of 59 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Ophid Interaction: APOB — HSPA5 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Qiu et al., Arterioscler Thromb Vasc Biol 2005 (Carcinoma, Hepatocellular...) : To investigate the role of glucosamine mediated endoplasmic reticulum ( ER ) stress and Grp78 ( BiP ) in the intracellular degradation of apolipoprotein B100 (apoB100) in cultured hepatocytes ... Adenoviral overexpression of Grp78 also led to significantly decreased levels of newly synthesized apoB100 in a dose dependent manner ( P < 0.01 ) ... Grp78 induced downregulation of apoB100 was sensitive to inhibition by the proteasome inhibitor, lactacystin, but not lysosomal protease inhibitors, E64 and leupeptin, suggesting that overexpression of Grp78 selectively induced proteasomal degradation of apoB100
Chen et al., Life Sci 2007 : All modified LDL significantly suppressed ATP synthase, Grp58, Grp78 , and Prdx3
Yao et al., Biochim Biophys Acta 2012 : In addition, the upregulation of p-IRE1 and GRP78 and the nuclear translocation of ATF6 induced by mm-LDL were significantly attenuated by TLR4 siRNA
Rosenes et al., PloS one 2013 : ELISA experiments showed cross competition with LDL inhibiting PAT-SM6 binding to immobilised GRP78 , while, in the reverse experiment, GRP78 inhibited PAT-SM6 binding to immobilized LDL