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ANGPT2 — SPP1

Text-mined interactions from Literome

Xie et al., J Cell Physiol 2001 : This study tested whether ANG II induces osteopontin expression in adult rat ventricular myocytes and cardiac microvascular endothelial cells ( CMEC ), and if so, whether induction is mediated via activation of mitogen activated protein kinases ( p42/44 MAPK ) and involves reactive oxygen species ( ROS ) ... ANG II stimulated osteopontin expression in CMEC in a time- ( within 4 h ) and concentration dependent manner, which was prevented by the AT1 receptor antagonist, losartan
Xie et al., J Cell Physiol 2004 : Thus, Ang II alone increases OPN expression, while IL-1beta and TNF-alpha act synergistically with Ang II to increase OPN mRNA possibly via NO independent mechanisms
Lou et al., Zhonghua Yi Xue Za Zhi 2004 : ( 2 ) Following excitation by Ang II in vitro, there was substantial up-regulation of OPN mRNA expression in RAW264.7 macrophages with dose dependent ; with a dose of 1 micromol/L incubated for 12 h, Ang II increased the OPN mRNA expression by 2.6 folds ( P < 0.01 )
Weisberg et al., Arterioscler Thromb Vasc Biol 2005 (Aortic Diseases...) : Ang II increased aortic mRNA expression of PAI-1, collagen I, collagen III, fibronectin, osteopontin , monocyte chemoattractant protein-1, and F4/80 ; PAI-039 significantly decreased the Ang II-induced increase in aortic osteopontin expression at 8 weeks
Qiu et al., Pharmazie 2012 : Here we show that, in primary cultured rat VSMCs, Ang-II exhibits chemotactic effect on cultured VSMCs and induces OPN expression dose-dependently ... Our results demonstrated that OPN is required for Ang-II to induce VSMCs migration and suggested OPN as a potential target in preventing atherosclerotic development