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EPHB2 — GDF15
Text-mined interactions from Literome
Gerecke et al., Mol Cell Neurosci 2004
:
NRG-1beta effects on neurite extension and arborization are similar to, but not additive with, those of brain derived neurotrophic factor and reflect direct NRG-1 action on hippocampal neurons as these cells express the NRG-1 receptors erbB2 and erbB4, the erbB-specific inhibitor PD158780 decreases NRG-1beta induced neurite outgrowth, and
NRG-1beta stimulation
induces p42/44
ERK phosphorylation
Wollmann et al., Carcinogenesis 2005
(Breast Neoplasms) :
MIC-1 increased the basal
ERK1 phosphorylation and prolonged the estrogen stimulated ERK1 phosphorylation in MCF-7 breast cancer cells without altering the phosphorylation status of AKT/PKB
Nakaoka et al., J Clin Invest 2007
(Cardiovascular Abnormalities...) :
NRG-1beta induced
activation of both
ERK and AKT in the hearts of control mice but not in those of DKO mice
Kim et al., Cancer Lett 2008
(Breast Neoplasms...) :
Adipocyte culture medium- and palmitate induced
MIC-1 gene expression was
mediated by the activation of p38 MAPK, but not by the activation of JNK,
ERK , and NF-kappaB pathway
Park et al., BMB Rep 2010
(Breast Neoplasms) :
MIC-1 induced significant phosphorylation of EGFR at Tyr845, ErbB2 at Tyr877, and ErbB3 at Tyr1289 as well as Akt and p38,
Erk1/2 , and JNK mitogen activated protein kinases ( MAPKs )
Yu et al., J Cell Physiol 2012
(Adenocarcinoma...) :
Furthermore, the activity of
ERK1/2 was enhanced by the combination of K8 and paclitaxel, and an ERK1/2 inhibitor dramatically
inhibited NAG-1 expression in human lung cancer cells
Choi et al., Protein & cell 2012
(MAP Kinase Signaling System) :
While over expression of the intact human HER3 transformed CHO cells with oncogenic properties such as AKT/ERK activation and increased proliferation and migration, CHO cells expressing the HER3-2-3 chimeric receptor showed significantly reduced HER3/HER2 dimerization and decreased phosphorylation of both AKT and
ERK1/2 in the
presence of
neuregulin-1 (NRG-1)