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UTP6 — VCAM1

Text-mined interactions from Literome

Seye et al., J Biol Chem 2003 : The P2Y2 nucleotide receptor mediates UTP induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells ... P2Y2 antisense oligonucleotides inhibited VCAM-1 expression induced by UTP but not by tumor necrosis factor-alpha ... Furthermore, UTP induced VCAM-1 expression in human 1321N1 astrocytoma cell transfectants expressing the recombinant P2Y2 receptor, whereas vector transfected control cells did not respond to UTP ... The effect of UTP on VCAM-1 expression in HCAEC was prevented by depletion of intracellular calcium stores with thapsigargin or by inhibition of p38 mitogen activated protein kinase or Rho kinase, but was not affected by inhibitors of the mitogen activated protein/extracellular signal regulated kinase pathway ( i.e. MEK1/2 )
Seye et al., J Biol Chem 2004 (Arteriosclerosis) : Deletion or mutation of two Src homology-3 binding sites in the C-terminal tail of the P2Y(2)R or inhibition of Src kinase activity abolished the P2Y(2)R mediated transactivation of VEGFR-2 and subsequently inhibited UTP induced VCAM-1 expression
Baker et al., Mol Immunol 2008 : Moreover, silencing of EGFR expression abolished UTP induced VCAM-1 up-regulation in HSG cells