Epling-Burnette et al., J Immunol 2001
:
Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony stimulating factor delayed apoptosis in human neutrophils ... We examined the hypothesis that Janus kinase/STAT and PI 3-kinase regulation of Mcl-1 contributed to GM-CSF delayed apoptosis
Song et al., Chin J Cancer 2002
(Multiple Myeloma) :
IL-6 inhibited apoptosis of XG-7 cells through up-regulation of Mcl-1 and the activation of JAK/STAT rather than Ras/MAPK nor PI-3K/Akt signal transduction pathway
Wu et al., Chin J Cancer 2009
(Nasopharyngeal Neoplasms) :
This study was to investigate the effects of a JAK inhibitor, AG490, on the proliferation, apoptosis, and expressions of apoptosis related survivin and Mcl-1 genes, thus to explore the role of JAK-STAT3 signaling pathway in the regulation of cell apoptosis in nasopharyngeal carcinoma (NPC) cell line CNE-2Z
Jiang et al., J Hepatol 2009
:
Mcl-1 expression was upregulated in a JAK dependent manner