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CDK4 — CIB2
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Feinberg et al., Cancer Res 1999
(Neoplasms) :
Our laboratory has found genomic imprinting of a large genomic domain of human 11p15.5, identifying six imprinted genes within this domain : ( a ) insulin-like growth factor II (IGF-II), an important autocrine growth factor in a wide variety of malignancies ; ( b ) H19, an untranslated RNA that is a putative growth suppressor gene regulating IGF-II ; ( c )
p57KIP2 , a
cyclin dependent kinase inhibitor that causes G1-S arrest ; ( d ) KvLQT1, a voltage gated potassium channel ; ( e ) TSSC3, a gene that is homologous to mouse TDAG51, which is implicated in Fas mediated apoptosis; and (f) TSSC5, a putative transmembrane protein encoding gene
Billotte et al., Biomed Sci Instrum 2001
:
The expression of
p57kip2 , a
cyclin dependent kinase inhibitor , is a strong indicator that the cells are exiting the cell cycle and are beginning to differentiate
Huang et al., J Clin Invest 2012
(Heart Defects, Congenital) :
Expression of
p57kip2 , a BMP10 regulated
cyclin dependent kinase inhibitor , was induced in Myocd-/- hearts, while BMP10 activated cardiogenic transcription factors, including NKX2.5 and MEF2c, were repressed
Lee et al., Genes Dev 1995
:
Cloning of
p57KIP2 , a
cyclin dependent kinase inhibitor with unique domain structure and tissue distribution