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CALM2 — EPHB2
Text-mined interactions from Literome
Lee et al., Brain Res Mol Brain Res 2000
:
This finding indicates that the
calmodulin dependent activation of
ERK and p38 kinase is involved in calcium induced c-fos expression
Rosengart et al., Shock 2000
:
Interactions of
calcium/calmodulin dependent protein kinases ( CaMK ) and
extracellular regulated kinase (ERK) in monocyte adherence and TNFalpha production
Stocco et al., J Biol Chem 2002
:
A
calcium/calmodulin dependent activation of
ERK1/2 mediates JunD phosphorylation and induction of nur77 and 20alpha-hsd genes by prostaglandin F2alpha in ovarian cells
Ferrer et al., J Neural Transm 2001
(Alzheimer Disease...) :
Calcium/calmodulin dependent kinase II ( alpha- and beta-CaM kinase II ), and phosphorylated mitogen activated extracellular signal regulated protein kinase (
MAPK/ERK-P ), phosphorylated protein kinase of 38 kDa ( p38-P ) and phosphorylated stress activated protein kinase ( SAPK/JNK-P ) expression have been examined in Alzheimer disease (AD), Pick's disease (PiD), progressive supranuclear palsy ( PSP ) and corticobasal degeneration (CBD)
Verploegen et al., Eur J Biochem 2002
(Calcium Signaling) :
Inhibition of
calmodulin using a calmodulin antagonist N- ( 6-aminohexyl ) -5-chloro-1-naphthalenesulfonamide ( W7 ), did not effect N-formyl-methionyl-leucyl-phenylalanine ( fMLP )
induced ERK , p38 MAPK or GSK-3alpha phosphorylation, but attenuated fMLP induced PKB phosphorylation
Arnette et al., J Biol Chem 2003
:
In particular,
calmodulin antagonists, FK506, and cyclosporin, immunosuppressants that inhibit the calcium dependent phosphatase calcineurin,
suppress ERK1/2 activation by both glucose and GLP-1
Sgambato et al., J Neurochem 2003
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This effect depended on the activation of NMDA receptors but was independent of both
calcium/calmodulin dependent protein kinases ( CaMK ) and
extracellular regulated kinase (ERK)
Kameshita et al., J Biochem Biophys Methods 2004
:
One of the antibodies obtained, KI98, detected a variety of purified Ser/Thr protein kinases, such as
calmodulin dependent protein kinase II ( CaM-kinase II ), calmodulin dependent protein kinase IV ( CaM-kinase IV ), cAMP dependent protein kinase, protein kinase C, and
Erk2
Xie et al., Neuromolecular Med 2004
(Alzheimer Disease...) :
Interestingly, acute application of Abeta or APP overexpression inhibits activity dependent regulation of several protein kinase pathways that require Ca2+ influx via NMDA receptors for activation, including
Ca2+/calmodulin dependent protein kinase II, protein kinase A, and
extracellular regulated kinases (Erk)
Méndez-Samperio et al., J Infect 2006
(Calcium Signaling...) :
Activation of
ERK1/2 and TNF-alpha production are
mediated by
calcium/calmodulin , and PKA signaling pathways during Mycobacterium bovis infection
Norum et al., FEBS Lett 2007
(Calcium Signaling...) :
However, serotonin stimulated phosphorylation of endogenous and recombinant Ras-GRF1, increased [ Ca ( 2+ ) ] ( i ) and caused Ca ( 2+ ) - and
calmodulin dependent
ERK1/2 phosphorylation
Cammarota et al., Proc Natl Acad Sci U S A 2008
(Amnesia) :
IA training is followed by an increase of the phosphorylation of calcium and
calmodulin dependent protein kinase II ( CaMKII ) and
ERK2 in CA1 but only an increase of the phosphorylation of ERK2 in BLA
Cipolletta et al., Endocrinology 2010
:
Calcium dependent signaling through
calcium/calmodulin dependent kinase II ( CaMKII ) and
ERK1/2 activation plays an important role in the regulation of VSMC proliferation by agents such as alpha-adrenergic receptor agonists
Kitao et al., Neurochem Int 2010
(Calcium Signaling) :
Inhibitors of intracellular Ca ( 2+ ) -dependent proteins such as calpain and
calmodulin blocked SNP induced
ERK phosphorylation and decrease in cell viability
Abbott et al., J Appl Physiol 2011
(Calcium Signaling) :
Glucose uptake rates were blunted in caffeine treated DN mice ( P < 0.05 ). The DN transgene resulted in a greater use of intramuscular triglycerides as a fuel source during muscle contraction. The DN transgene did not alter caffeine- or contraction mediated changes in the phosphorylation of Ca ( 2+ )
/calmodulin dependent protein kinase I or
ERK1/2 ( P > 0.05 )
Moncada et al., Proc Natl Acad Sci U S A 2011
:
Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required a-Ca ( 2+ )
/calmodulin dependent protein kinase II and PKA but not
ERK1/2 activity
Lucki et al., Mol Cell Endocrinol 2012
(Calcium Signaling...) :
S1P induced StAR mRNA expression requires Ga ( i ) signaling, phospholipase C (PLC), Ca ( 2+ )
/calmodulin dependent kinase II ( CamKII ), and
ERK1/2 activation
Guo et al., Exp Cell Res 2012
:
Also,
ERK and CREB phosphorylation was not
mediated by protein kinase A (PKA) or
calmodulin kinase ( CaMK )
Kramarenko et al., Cancer management and research 2012
:
Inhibitor studies suggest that BK-induced
ERK activation requires phospholipase C and protein kinase C activities, and is Ca ( 2+ )
/calmodulin dependent
Egea et al., J Neurochem 1998
(Ion Channel Gating) :
These data suggest that
calmodulin mediates
ERK activation induced by increases in intracellular Ca2+ concentration in PC12 cells by a mechanism that seems to be independent of Trk A and EGFR activation
Bosch et al., J Biol Chem 1998
:
Because calmodulin is essential for quiescent cells to enter cell cycle, the
role of
calmodulin on
ERK2 activation was studied in cultured fibroblasts
Murasawa et al., Hypertension 1998
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These findings demonstrate that in cardiac fibroblasts, Ang II induced
Ras/ERK activation is dominantly
regulated by Gq-coupled
Ca2+/calmodulin signaling and that Pyk2 plays an important role in the signal transmission for efficient activation of the Ang II induced Ras/ERK pathway