Sui et al., Br J Haematol 2000
:
We have recently demonstrated that SCF and EPO synergistically activate mitogen activated protein ( MAP ) kinase , thereby promoting growth of human erythroid colony forming cells ( ECFCs )
Jeong et al., Int J Cancer 2008
(Ovarian Neoplasms) :
The EpoR on A2780 cells was shown to be functional, since Epo stimulation resulted in phosphorylation of Erk1/2 , an important EpoR mitogenic signaling intermediate
Klingmüller et al., Eur J Biochem 1997
:
The signal emanating from Y479 involves sequential EPO induced recruitment of phosphoinositol lipid 3-kinase to the EPO-R and activation of mitogen-activated-protein ( MAP ) kinase activity
Sui et al., Blood 1998
:
Together, the data suggest that synergistic activation of MAPK by SCF and EPO is essential for expanded erythropoiesis