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EDN1 — SERPINB3

Text-mined interactions from Literome

Satoh et al., Respiration 1992 : Potential difference ( PD ) and short-circuit current (SCC) were measured using an Ussing chamber with 0.5 cm2 of exposed area, and conductance ( G ) was calculated by dividing SCC by PD. Luminal endothelin-1 produced transient increases in PD and SCC , returning to baseline values within 5 min after stimulation in a dose dependent fashion and reached mean responses of 123 and 126 % of baseline PD and SCC, respectively, at 10 ( -6 ) M of endothelin-1, whereas submucosal endothelin-1 did not alter PD and SCC
Wong et al., J Cardiovasc Pharmacol 1991 : The stimulation of SCC by endothelin was likely to be due to an increase to anion secretion as removal of Cl from the incubation medium markedly reduced the SCC response to endothelin ... Diphenylamine-2-carboxylate ( DPC, 0.1 mM ), a Cl-channel blocker, added to the apical side also inhibited the endothelin induced rise in SCC ... The stimulation of SCC by endothelin was accompanied by a rise in the intracellular cyclic AMP content in epididymal monolayers
Wong et al., Br J Pharmacol 1989 : 3. The stimulation of SCC by endothelin was accompanied by a rise in the intracellular adenosine 3 ' : 5'-cyclic monophosphate ( cyclic AMP ) content in epididymal monolayers ... 4. The effect of endothelin on SCC was mediated through an increase in prostaglandin synthesis by the tissues and was not blocked by an antagonist of angiotensin II ( Sar1 Ile8 angiotensin II ) or of adrenaline ( propranolol )