Gene interactions and pathways from curated databases and text-mining

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EDN1 — F2R

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Baker et al., FEBS Lett 2008 (Inflammation) : Combining high-resolution fluorescence microscopy and functional assays, we found that activation of the GPCRs PAR-1 and ET ( A/B ) by their natural inflammatory mediator agonists, thrombin and endothelin-1 , resulted in rapid and acute internalization of gap junctions ( GJs ) that coincided with the inhibition of GJIC followed by increased vascular permeability
Chen et al., Biochem Biophys Res Commun 1995 : Endothelin-1 does not induce thrombin receptor degradation nor change in thrombin receptor mRNA level after 2 h and 24 h of incubation