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CD4 — STAT4

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12 signaling mediated by STAT4: STAT4 (dimer) complex (STAT4) → TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4) (transcription, activates)
  Szabo et al., Science 2002, Wittmann et al., J Leukoc Biol 2006
  Evidence: mutant phenotype, assay, other species

Text-mined interactions from Literome

Carter et al., J Exp Med 1999 : Both lineages require signal transducer and activator of transcription ( Stat ) 4 activation for IFN-gamma induced by interleukin (IL)-12/IL-18 signaling, but only CD4 ( + ) T cells require Stat4 for IFN-gamma induction via the TCR pathway ... In response to antigen, CD8 ( + ) T cells can produce IFN-gamma independently of IL-12, whereas CD4 ( + ) T cells require IL-12 and Stat4 activation
Lim et al., J Immunol 2001 : IL-12, STAT4 dependent up-regulation of CD4 ( + ) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands