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IGF1 — RAF1

Pathways - manually collected, often from reviews:

• BioCarta multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation: IGF-1/IGF-1/IGF-1R-alpha/IGF-1R-alpha/IGF-1R-beta/IGF-1R-beta/14-3-3 complex (IGF1R-YWHAH-IGF1) → RAF1 (modification, activates)

Text-mined interactions from Literome

Kawaguchi et al., Clin Exp Allergy 2010 : MAP kinase kinase ( MEK ) inhibitors and the Raf1 kinase inhibitor significantly inhibited IGF-I production, and the combination of PD98059 and Raf1 kinase inhibitor showed further inhibition
Lorenzo et al., J Cell Biol 1993 : IGF-I or 10 % FCS, however, similarly increased the mRNA late expression of c-myc, H-ras, c-raf , beta-actin, and glucose 6-phosphate dehydrogenase (G6PD) at 72 h, as compared to quiescent cells
Sanz et al., Oncogene 1999 : c-Raf activity was increased in response to insulin like growth factor-I (IGF-I) and the activation by IGF-I of the c-Raf kinase pathway was a requirement to turn on cell proliferation in the otic vesicle