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FLT4 — VEGFA
Pathways - manually collected, often from reviews:
-
KEGG Focal adhesion:
EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD/PGF/VEGFA/VEGFB/VEGFC
→
EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB
(protein-protein, activation)
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA189 (dimer) complex (VEGFA)
→
VEGFR2/3 (dimer)/VEGFA189 (dimer) complex (FLT4-KDR-VEGFA)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA189 (dimer) complex (VEGFA)
→
VEGFR3 (FLT4)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR2/3 (dimer)/VEGFA189 (dimer) complex (FLT4-KDR-VEGFA)
→
VEGFR2 (KDR)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR2/3 (dimer)/VEGFA189 (dimer) complex (FLT4-KDR-VEGFA)
→
VEGFR3 (FLT4)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA121 (dimer) complex (VEGFA)
→
VEGFR2/3 (dimer)/VEGFA121 (dimer) complex (FLT4-KDR-VEGFA)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA121 (dimer) complex (VEGFA)
→
VEGFR3 (FLT4)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR2/3 (dimer)/VEGFA121 (dimer) complex (FLT4-KDR-VEGFA)
→
VEGFR2 (KDR)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR2/3 (dimer)/VEGFA121 (dimer) complex (FLT4-KDR-VEGFA)
→
VEGFR3 (FLT4)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA (dimer) complex (VEGFA)
→
VEGFR2/3 (dimer)/VEGFA (dimer) complex (FLT4-KDR-VEGFA)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA (dimer) complex (VEGFA)
→
VEGFR3 (FLT4)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR2/3 (dimer)/VEGFA (dimer) complex (FLT4-KDR-VEGFA)
→
VEGFR2 (KDR)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR2/3 (dimer)/VEGFA (dimer) complex (FLT4-KDR-VEGFA)
→
VEGFR3 (FLT4)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA (dimer) complex (VEGFA)
→
VEGFR2/3 (dimer)/VEGFA (dimer)/NRP2 complex (FLT4-KDR-VEGFA-NRP2)
(modification, collaborate)
Favier et al., Blood 2006
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA (dimer) complex (VEGFA)
→
VEGFR3 (FLT4)
(modification, collaborate)
Favier et al., Blood 2006
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR2/3 (dimer)/VEGFA (dimer)/NRP2 complex (FLT4-KDR-VEGFA-NRP2)
→
NRP2 (NRP2)
(modification, collaborate)
Favier et al., Blood 2006
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR2/3 (dimer)/VEGFA (dimer)/NRP2 complex (FLT4-KDR-VEGFA-NRP2)
→
VEGFR2 (KDR)
(modification, collaborate)
Favier et al., Blood 2006
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR2/3 (dimer)/VEGFA (dimer)/NRP2 complex (FLT4-KDR-VEGFA-NRP2)
→
VEGFR3 (FLT4)
(modification, collaborate)
Favier et al., Blood 2006
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA145 (dimer) complex (VEGFA)
→
VEGFR2/3 (dimer)/VEGFA145 (dimer) complex (FLT4-KDR-VEGFA)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFA145 (dimer) complex (VEGFA)
→
VEGFR3 (FLT4)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR2/3 (dimer)/VEGFA145 (dimer) complex (FLT4-KDR-VEGFA)
→
VEGFR2 (KDR)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
NCI Pathway Database VEGF and VEGFR signaling network:
VEGFR2/3 (dimer)/VEGFA145 (dimer) complex (FLT4-KDR-VEGFA)
→
VEGFR3 (FLT4)
(modification, collaborate)
Nilsson et al., EMBO J 2010
Evidence: physical interaction
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16
→
FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK
(activation)
Text-mined interactions from Literome
Baldwin et al., J Biol Chem 2001
:
Human
vascular endothelial growth factor-D ( VEGF-D ) binds and
activates VEGFR-2 and
VEGFR-3 , receptors expressed on vascular and lymphatic endothelial cells
Witmer et al., Invest Ophthalmol Vis Sci 2002
(Diabetic Retinopathy) :
In diabetic eyes, expression of retinal VEGFR-2 and -3 is increased, mainly in leaky microvessels, and
VEGF-A induces vascular expression of the VEGF-A receptor VEGFR-2 and the VEGF-C/D receptor
VEGFR-3
Krishnan et al., Cancer Res 2003
(Lymphatic Metastasis...) :
A number of clinical and experimental studies suggest that tumor induced lymphangiogenesis driven by
vascular endothelial growth factor ( VEGF ) -C- and/or VEGF-D induced
activation of VEGF receptor
(VEGFR)-3 may promote metastasis to regional lymph nodes
Dixelius et al., J Biol Chem 2003
(Neovascularization, Pathologic) :
Interestingly,
VEGF-C stimulation of lymphatic endothelial cells also
induced the formation of
VEGFR-3/VEGFR-2 heterodimers, in which VEGFR-3 was phosphorylated only at three of the five sites while the two most carboxyl-terminal tyrosine residues appeared not to be accessible for the VEGFR-2 kinase
Orlandini et al., J Biol Chem 2006
:
Moreover, in primary human osteoblasts,
VEGF-D expression is under the control of VEGF, and inhibition of
VEGF-D/VEGFR-3 signaling, by monoclonal antibodies or VEGFR-3 silencing,
affects VEGF dependent osteoblast differentiation
Zhao et al., Br J Ophthalmol 2006
(Choroidal Neovascularization) :
VEGF-A , but not glucose alone,
stimulated VEGFR-3 mRNA expression
Kulkarni et al., Mech Dev 2009
:
In vitro, endogenous and
VEGF-A induced
VEGFR-3 and podoplanin expression by human microvascular endothelial cells was reduced by siRNA to NFATc1, to levels comparable to reductions seen with siRNA to Prox-1
Mancinelli et al., Experimental biology and medicine (Maywood, N.J.) 2009
:
We have shown that : ( i ) cholangiocytes express VEGFR-2 and
VEGFR-3 ; ( ii )
VEGF-A and VEGF-C
stimulate cholangiocyte proliferation via an autocrine mechanism ; and ( iii ) chronic administration of VEGF-A prevents cholangiocyte damage induced by hepatic artery ligation
Gavrilovskaya et al., J Virol 2012
:
However,
VEGF-C activation of LEC-specific
VEGFR3 receptors blocked ANDV- and VEGF-A induced LEC permeability
Pajusola et al., Oncogene 1994
:
Also,
FLT4 did not interact with KDR in
response to
VEGF
Joukov et al., J Biol Chem 1998
:
VEGF activates the endothelial VEGF receptors (VEGFR) 1 and 2, and VEGF-C
activates VEGFR-3 and VEGFR-2