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HMGB1 — INS
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Burg et al., Cell Metab 2008
:
Ins1 dependent phosphorylation of
Hmg1 requires the MAP kinase Sty1/Spc1, and Hmg1 phosphorylation is physiologically regulated by nutrient stress
Burg et al., J Biol Chem 2011
:
In contrast to the mammalian system,
Ins1 regulates
Hmg1 by a nondegradative mechanism involving phosphorylation of the Hmg1 active site ... We show that
Ins1 dependent
Hmg1 phosphorylation is strongly induced in response to glucose withdrawal and that HMGR activity is correspondingly reduced