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CCR7 — TLR8
Text-mined interactions from Literome
Larangé et al., J Leukoc Biol 2009
:
TLR7 and
TLR8 activation
up-regulated CCR7 , CD40, CD86, and CD83 expression and IL-6 and IL-12p40 production
Muthuswamy et al., Blood 2010
(Melanoma) :
In contrast to the PGE ( 2 ) -matured DCs, DCs matured in the
presence of
toll-like receptor ( TLR ) ligands and interferons produce high levels of both CCL19 and CCR7 mRNA/protein, but show selectively reduced expression of surface
CCR7 , which is compensated after DC removal from the CCL19-rich maturation environment
Hanley et al., PLoS Pathog 2010
(HIV Infections) :
Here, we show that ligands for peroxisome proliferator activated receptor gamma ( PPARgamma ) and liver X receptor ( LXR ) prevented proinflammatory cytokine production by DCs and inhibited DC migration in response to the chemokine CCL21 by preventing the
TLR induced upregulation of
CCR7