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NF1 — TP53

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TP53 → NF1 (decreases)
  Evidence: loss of neurofibromin induced the accumulation of p53 and the activation of Rb, as demonstrated by reduced levels of hyperphosphorylated Rb (Figure 2A).

Text-mined interactions from Literome

Lee et al., Biochem Cell Biol 1999 : NF1 or YY1 binds to the motif and regulates the expression of the human p53 gene in a tissue-specific manner
Nayak et al., Mol Biol Rep 1999 (Breast Neoplasms) : Recently, a tissue specific binding of NF1/YY1 to p53 promoter has been reported and further, it has been demonstrated that NF1/YY1 activates p53 promoter activity ... Hence it is assumed that p53 expression is not NF1 dependent in breast tumours
Furlong et al., Mol Cell Biol 1996 : YY1 and NF1 both activate the human p53 promoter by alternatively binding to a composite element, and YY1 and E1A cooperate to amplify p53 promoter activity