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PXN — TLN1

Pathways - manually collected, often from reviews:

• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, collaborate)
  
• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → PIP2/Gelsolin complex (GSN) (actin filament polymerization, collaborate)
  
• BioCarta ucalpain and friends in cell spread: FODRIN (SPTAN1) → Paxillin/FAK/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-PTK2-TLN1-SPTAN1-ITGA1-ITGB1-SRC-VIL2) (modification, collaborate)
  
• BioCarta ucalpain and friends in cell spread: Calpain1 complex (CAPNS1-CAPN1) → Paxillin/FAK/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-PTK2-TLN1-SPTAN1-ITGA1-ITGB1-SRC-VIL2) (modification, activates)
  
• BioCarta ucalpain and friends in cell spread: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → Paxillin/FAK/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-PTK2-TLN1-SPTAN1-ITGA1-ITGB1-SRC-VIL2) (modification, collaborate)
  
• BioCarta integrin signaling pathway: None → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  
• BioCarta integrin signaling pathway: Zyxin (ZYX) → ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) (modification, collaborate)
  
• BioCarta integrin signaling pathway: Zyxin (ZYX) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  
• BioCarta integrin signaling pathway: CSK → ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) (modification, collaborate)
  
• BioCarta integrin signaling pathway: CSK → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → Tensin (TNS1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → FAK (PTK2) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → NOLC1 (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → Calpain1 (CAPN1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → Actin (ACTA1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → Tensin (TNS1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → FAK (PTK2) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → NOLC1 (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → Calpain1 (CAPN1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → Actin (ACTA1) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) → alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Calpastatin (CAST) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, inhibits)
  
• BioCarta mcalpain and friends in cell motility: Actin (ACTA1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Calpain1 complex (CAPNS1-CAPN1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, activates)
  
• BioCarta mcalpain and friends in cell motility: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: Rho-Kinase Dia/Profilin complex (PFN1-DIAPH1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) (actin filament polymerization, activates)
  
• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: Rho-Kinase Dia/Profilin complex (PFN1-DIAPH1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, activates)
  
• BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → Paxillin/FAK/Talin/MLC/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → myosin light chain protein kinase (MYLK) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) → Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-TLN1-ITGB1) (modification, collaborate)
  
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1) (modification, collaborate)
• BioCarta integrin signaling pathway: Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-TLN1-ITGB1) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: RAC1 → Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) (modification, activates)
  
• BioCarta ucalpain and friends in cell spread: Talin (TLN1) → Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) (modification, collaborate)
  
• BioCarta ucalpain and friends in cell spread: Talin (TLN1) → PAX (PXN) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → FODRIN (SPTAN1) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → Actin (ACTA1) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → Ezrin (VIL2) (modification, collaborate)
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4) (modification, collaborate)
  
• BioCarta ucalpain and friends in cell spread: Paxillin/alpha-actinin/Talin/SPTAN1/Integrin-alpha/Integrin-beta/ECM/SRC/Ezrin complex (PXN-ACTN3_ACTN2_ACTN1_ACTN4-TLN1-SPTAN1-ITGA1-ITGB1-VIL2) → PAX (PXN) (modification, collaborate)
• BioCarta mcalpain and friends in cell motility: Calpastatin (CAST) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, inhibits)
  
• BioCarta mcalpain and friends in cell motility: Actin (ACTA1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Ezrin (VIL2) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, activates)
  
• BioCarta mcalpain and friends in cell motility: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → Paxillin/FAK/Talin/Actin/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-ACTA1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: MLC (MLC1) → Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → Calpain2 complex (CAPNS1-CAPN2) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B) (modification, collaborate)
  
• BioCarta mcalpain and friends in cell motility: Paxillin/FAK/Talin/MLC(+)/Integrin-alpha/Integrin-beta/ECM complex (PXN-PTK2-TLN1-MLC1-ITGA1-ITGB1) → Calpastatin (CAST) (modification, collaborate)
• BioCarta integrin signaling pathway: ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1) → ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN) (actin filament polymerization, collaborate)
  
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → Talin (TLN1) (modification, collaborate) Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: alpha4/beta1 Integrin/VCAM1/Paxillin complex (VCAM1-PXN-ITGA4-ITGB1) → alpha4/beta1 Integrin/VCAM1/Paxillin/Talin complex (VCAM1-PXN-TLN1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Alpha4 beta1 integrin signaling events: Talin (TLN1) → alpha4/beta1 Integrin/VCAM1/Paxillin/Talin complex (VCAM1-PXN-TLN1-ITGA4-ITGB1) (modification, collaborate)
  Alon et al., J Cell Biol 2005
  Evidence: mutant phenotype
• Reactome Reaction: PXN → TLN1 (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: TLN1 — PXN de Hoog et al., Cell 2004
• IRef Bind_translation Interaction: TLN1 — PXN (coimmunoprecipitation) de Hoog et al., Cell 2004
• IRef Biogrid Interaction: TLN1 — PXN (physical association, affinity chromatography technology) Salgia et al., Exp Hematol 1996*
• IRef Biogrid Interaction: TLN1 — PXN (direct interaction, pull down) Mazaki et al., J Biol Chem 1997*
• IRef Biogrid Interaction: TLN1 — PXN (direct interaction, pull down) Salgia et al., J Biol Chem 1995*
• MIPS CORUM Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1): Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) complex (ACTN1-BCAR1-CDH1-CTNNB1-JUP-PKD1-PTK2-PXN-SRC-TLN1-VCL) Geng et al., Biochim Biophys Acta 2000
• IRef Corum Interaction: Complex of 12 proteins (association, cosedimentation through density gradient) Geng et al., Biochim Biophys Acta 2000
• IRef Hprd Interaction: PXN — TLN1 (in vivo) Salgia et al., J Biol Chem 1995*
• IRef Ophid Interaction: TLN1 — PXN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Weaver et al., J Cell Biochem 2006 : Proteins associated with focal adhesions were increased in SPARC-null versus wild-type lens cells : levels of alpha6-integrin heterodimers, talin , and paxillin phosphorylated on tyrosine were enhanced significantly, as was the association of beta1-integrin with talin and paxillin
Brown et al., J Mol Biol 2011 (HIV Infections) : Together, these findings demonstrate that talin-1 and vinculin negatively affect tyrosine phosphorylation of paxillin , a novel positive regulator of HIV-1 infection, and impose an early block to infection by distinct retroviruses