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STX2 — TNF

Text-mined interactions from Literome

Zhang et al., Experimental biology and medicine (Maywood, N.J.) 2001 : The results showed that anisodamine suppressed Stx2 induced TNF-alpha production in a dose- and time dependent manner ... Anisodamine also suppressed Stx2 induced TNF-alpha mRNA expression ... Taken together, our results indicate that anisodamine has an important regulatory effect on Stx2 induced TNF-alpha production in vitro and in vivo
Nakamura et al., J Am Soc Nephrol 2001 : It has been shown that Stx-2 induces TNF-alpha production and that activation of beta ( 2 ) -adrenoceptors downregulates TNF-alpha ... However, little is known about the signaling pathway by which beta(2)-adrenoceptor agonists suppress the Stx-2 induced TNF-alpha gene transcription ... Stx-2 ( 4 pg/ml ) stimulated MAPK ( p42/p44, p38 ) and AP-1 and increased TNF-alpha promoter activity by 2.4-fold ... It is likely that cAMP-PKA and MAPK ( p42/p44, p38 ) may play a critical role in the regulation of the Stx-2 induced TNF-alpha transcription via beta(2)-adrenoceptor activation
Burdet et al., Br J Pharmacol 2013 (Premature Birth) : Our results demonstrate that the increased TNF-a and NO induced by Stx2 were the predominant factors responsible for preterm delivery in rats