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CASP4 — ITIH4
Text-mined interactions from Literome
Singh et al., J Neurovirol 2004
(Nerve Degeneration) :
Both HIV-1 Tat and
gp120 significantly
increased caspase-3 activation in a concentration dependent manner in striatal neurons at 4 h following continuous exposure in vitro ... Tat ( 1-72 ) and
gp120 caused significant neuronal losses at 48 h and/or 72 h. Tat ( 1-72 )
increased cytochrome c release, and
caspase-3 and endo G activation at 4 h, 24 h, and/or 72 h ... By contrast,
gp120 increased
caspase-3 activation, but failed to increase cytochrome c or endo G levels in the cytoplasm at 4 h, 24 h, and/or 72 h
Fiala et al., Cardiovasc Toxicol 2004
(Cardiomyopathies...) :
HIV-1,
gp120 , or Tat
induced Erk 1/2 phosphorylation, activation of
caspase-3 , and apoptosis of NRVMs and CAECs ; all of these were inhibited by a MAPK/ERK-kinase (MEK) inhibitor U0126
Singh et al., Neuroscience 2005
(Nerve Degeneration) :
Both Tat and
gp120 caused significant increases in p38 and c-jun-N-terminal kinase mitogen activated protein kinase phosphorylation,
caspase-3 activity, neurite losses and cell death in striatal neurons ... Alternatively,
gp120 induced increases in
caspase-3 activity, neurite losses and neuronal death were prevented by p38, but not c-jun-N-terminal kinase, mitogen activated protein kinase inhibition
Tun et al., J Neurochem 2007
:
As caspase-8 induced apoptosis does not typically require p53, we examined the possibility of a novel role for p53 in
caspase-8 activation
initiated by
gp120 ... We observed that
gp120 treatment of cultured cortical neurons
induced caspase-8 activity and Bid cleavage independently of p53, but induction of caspase-3 enzymatic activity required p53 expression
Alirezaei et al., J Neurosci 2007
(AIDS Dementia Complex) :
PKR inactivation also inhibited
gp120 induced
caspase-3 activation, consistent with its neuroprotective effect
Peng et al., J Neurovirol 2008
(Neuroblastoma) :
Additionally,
gp120 mediated activation of
caspase-3 was also significantly reduced in cells pretreated with PDGF-BB
Janda et al., Br J Pharmacol 2011
:
Tianeptine showed an anti-apoptotic effect and prevented
caspase-3 activation by
gp120