◀ Back to MAPK3

MAPK3 — SRC

Pathways - manually collected, often from reviews:

• Reactome Reaction: MAPK3 → SRC (reaction) Kuo et al., Cell Signal 2006, Luttrell et al., Science 1999*
• Reactome Reaction: MAPK3 → SRC (direct_complex) Kuo et al., Cell Signal 2006, Luttrell et al., Science 1999*

Text-mined interactions from Literome

Della Rocca et al., J Biol Chem 1999 : In all three cell types, GPCR stimulated Erk 1/2 activation is significantly inhibited by the Src kinase inhibitors, herbimycin A and 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo-D-3,4-pyrimidine ( PP1 ), suggesting that Src family nonreceptor tyrosine kinases represent a point of convergence for signals originating from either scaffold
Daly et al., Oncogene 1999 : All three ligands induced short-term activation of p38 MAPK in a c-Src dependent manner
Munshi et al., J Immunol 2000 (MAP Kinase Signaling System...) : Further studies using mutants of c-Src kinase revealed that Src mediates mitogen activated protein kinase activation induced by VEGF
Nebigil et al., Proc Natl Acad Sci U S A 2000 (MAP Kinase Signaling System) : Inhibition of c-Src activity by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidine ( PP1 ) or depletion of c-Src is sufficient to abolish the 5-HT induced ( i ) PDGFR tyrosine kinase phosphorylation and MAPK activation, ( ii ) cyclin D1 and cyclin E expression levels, and ( iii ) thymidine incorporation
Graness et al., Biochem J 2000 : Although Src does not participate in bradykinin induced stimulation of PTP activity, inhibition of Src by 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo ( 3,4-d ) pyrimidine leads to an increase in MAPK activation by bradykinin
Schmid et al., J Neurosci 2000 (MAP Kinase Signaling System...) : The nonreceptor tyrosine kinase pp60(c-src) was required for L1-triggered MAPK phosphorylation, as shown in src-minus cerebellar neurons and by expression of the kinase-inactive mutant Src ( K295M ) in B35 neuroblastoma cells
Bondzi et al., Cell Growth Differ 2000 (Carcinoma, Small Cell...) : Src family kinase activity is required for Kit mediated mitogen activated protein ( MAP ) kinase activation, however loss of functional retinoblastoma protein makes MAP kinase activation unnecessary for growth of small cell lung cancer cells
Robinson et al., Eur J Pharmacol 2001 : The Src tyrosine kinase inhibitor PP2 ( 4-amino-5- ( 4-chlorophenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidine ) and the epidermal growth factor receptor tyrosine kinase inhibitor AG1478 ( 4- ( 3-chloroanilino ) -6,7-dimethoxyquinazoline ) also had no effect on adenosine A(1) receptor stimulation of p42/p44 MAPK
Cammarota et al., J Neurochem 2001 (MAP Kinase Signaling System) : Our data support the hypothesis that in BACC, AII upregulates CREB functionality through a mechanism that requires Src mediated activation of ERK 1/2 and ( p90 ) RSK
Touyz et al., Hypertension 2002 (Hypertension) : We investigated whether upregulation of Src by Ang II leads to increased extracellular signal regulated kinase 1/2 ( ERK1/2 ) phosphorylation in vascular smooth muscle cells ( VSMCs ) from spontaneously hypertensive rats ( SHR ) and whether these processes are associated with altered activation of C-terminal Src kinase (Csk), a negative regulator of Src
Simeonova et al., Mol Cell Biochem 2002 : One of this pathways might include c-Src dependent EGFR and MAPK activation
Xu et al., Am J Pathol 2002 : Both a protein kinase C inhibitor, GF109203X, and a Src inhibitor, PP1, attenuated 5-HT stimulated Erk 1/2 activation
Xiang et al., Zhejiang Da Xue Xue Bao Yi Xue Ban 2003 : To further clarify the mechanism of Ang II-induced intracellular signal transduction in vascular smooth muscle cells ( VSMCs ) proliferation by observing the effect of c-Src on Ang II-mediated MAPK activation and c-fos protein expressions in rat VSMCs
Acosta et al., Mol Endocrinol 2003 : We initially observed that PRL dependent activation of focal adhesion kinase ( Fak ), Erk1/2 , and cell proliferation was mediated by c-Src in T47D cells, because expression of a dominant negative form of c-Src ( SrcDM, K295A/Y527F ) blocked the PRL dependent effects
Khadaroo et al., Surgery 2003 : Oxidant stress generated during global ischemia/reperfusion activates p38 MAPK in an Src dependent manner
Recchia et al., Bone 2004 (Adenocarcinoma, Clear Cell...) : c-Src inhibition stabilized p38 mitogen activated protein kinase ( MAPK ), whereas the c-Jun N-terminal kinase (JNK) pathway did not appear to be modulated by our compounds
Tejedo et al., Endocrinology 2004 : In addition, we found that NO produces c-Src/PI3K- and PKG dependent activation of ERK 1/2
Tsuruda et al., FEBS Lett 2004 (MAP Kinase Signaling System...) : Constitutively active Src facilitates NGF induced phosphorylation of TrkA and causes enhancement of the MAPK signaling in SK-N-MC cells
Salinthone et al., Am J Physiol Gastrointest Liver Physiol 2004 (Inflammation) : Expression of IL-1beta, IL-6, IL-8, and COX-2 mRNA was reduced by 30 microM PP1, an Src family tyrosine kinase inhibitor, and by 25 microM SB-203580, a p38 MAPK inhibitor
Waters et al., Cell Signal 2005 : Indeed, the PDGF dependent activation of p42/p44 MAPK was reduced by over-expression of the C-terminal domain of GRK2 ( sequesters Gbetagamma subunits ), the clathrin binding domain of beta-arrestin and by inhibitors of c-Src and clathrin mediated endocytosis
Amos et al., J Biol Chem 2005 (Glioblastoma) : The effects of PMA on MAPK phosphorylation and glioblastoma cell proliferation were reduced by BIM, rottlerin, the MEK inhibitor U0126, and PKCdelta and c-Src siRNAs
Callera et al., Hypertension 2005 : We tested the hypothesis that aldosterone induces activation of vascular mitogen activated protein ( MAP ) kinases and NADPH oxidase via c-Src dependent mechanisms in vascular smooth muscle cells ( VSMCs )
Zhou et al., Toxicological sciences : an official journal of the Society of Toxicology 2005 : MAPK phosphorylation by two other translational inhibitors, anisomycin and emetine, were similarly Src dependent
Zubkov et al., J Cardiovasc Pharmacol 2004 : The following results were observed : ( 1 ) endothelin-1 produced phosphorylation of MAPK and RhoA and contraction by activation of endothelin-A but not endothelin-B receptors ; ( 2 ) MAPK inhibitors, PD 98059 and U0126, PTK inhibitor, genistein, Src kinase inhibitor , damnacanthal, and Janus tyrosine kinase ( JAK2 ) inhibitor, AG-490, abolished endothelin-1 induced contraction and MAPK immunoreactivity ; ( 3 ) PTK inhibitor, staurosporine, and phosphatidylinositol 3-kinase (PI- 3K) inhibitor wortmannin abolished endothelin-1 induced contraction but not MAPK immunoreactivity ; ( 4 ) Rho-kinase inhibitor, Y-27632, reduced endothelin-1 induced contraction ; ( 5 ) PI-3K inhibitor, wortmannin, but not PKC and PTK inhibitors, reduced endothelin-1 induced RhoA activation ; ( 6 ) endothelin-1 increased the level of myosin light chain ( MLC ) phosphorylation, and Rho-kinase inhibitor, Y-27632, reduced the effect of endothelin- 1 on MLC phosphorylation
Wei et al., J Biol Chem 2005 (MAP Kinase Signaling System) : However, deletion of this region in the context of human RON enhanced receptor phosphorylation, activation of mitogen activated protein kinase , and association of c-Src at levels comparable with those observed with mouse RON
Gelain et al., Cell Signal 2006 : In this work, we report that, in Sertoli cells, retinol ( 7 microM ) induces the Src dependent activation of ERK1/2 MAPK and the ERK1/2 mediated phosphorylation of the transcription factor CREB
Simó et al., Cereb Cortex 2007 (MAP Kinase Signaling System) : The inhibition of Src family kinases (SFK) blocked Reelin dependent Erk1/2 activation
Carini et al., J Hepatol 2006 (Anoxia...) : ATPgammaS activated Src and promoted a Src dependent stimulation of both ERK1/2 and p38MAPK
Pardo et al., Biogerontology 2007 : Extracellular and intracellular Ca ( 2+ ) chelation or c-Src pharmacological inhibition suppressed hormone activation of p38 MAPK in both, young and aged rats, demonstrating that Ca ( 2+ ) and the non-receptor tyrosine kinase c-Src are required for full activation of p38 MAPK in cells stimulated with 1alpha,25 ( OH ) ( 2 ) D ( 3 )
Galliher et al., Breast Cancer Res 2006 (Breast Neoplasms...) : Inhibiting Src activity in MECs prevented the ability of beta3 integrin to induce TbetaR-II tyrosine phosphorylation, MAPK activation, and EMT stimulated by TGF-beta
Hodges et al., Invest Ophthalmol Vis Sci 2006 : Roles of protein kinase C, Ca2+, Pyk2, and c-Src in agonist activation of rat lacrimal gland p42/p44 MAPK
Fleming et al., Endocrinology 2006 : Unexpectedly, inhibition of Src increased basal MAPK activation
Faivre et al., Mol Cell Biol 2007 (Breast Neoplasms) : Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src dependent sustained activation of Erk1/2 mitogen activated protein kinase in breast cancer cells
Cheng et al., Endocrinology 2007 : In addition, we demonstrate that Src kinase is activated by T and that Src kinase activity is required for stimulation of the ERK MAPK and CREB
Jin et al., Cancer Res 2007 (Cell Transformation, Neoplastic) : Suppression of c-Src by RNA interference in NIH3T3-ETV6-NTRK3 cells resulted in markedly decreased expression of cyclin D1 and suppression of activation of Ras-Erk1/2 and PI3K-Akt
Galliher et al., Cancer Res 2007 (MAP Kinase Signaling System...) : Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion
Yaghini et al., J Biol Chem 2007 : These data suggest that Syk expressed in VSMC is activated by Ang II through p38 MAPK activated c-Src subsequent to cytosolic phospholipase A ( 2 ) and generation of AA metabolites via LO, and it mediates Ang II-induced protein synthesis independent of epidermal growth factor receptor transactivation ( Ang II -- > cPLA(2) -- > AA metabolites of LO -- > p38 MAPK -- > c-Src -- > Syk -- > protein synthesis )
Lim et al., Arch Biochem Biophys 2007 (MAP Kinase Signaling System) : Inhibition of c-Src suppressed Raf/MEK/ERK pathway but activated p38 MAPK ... Inhibition of p38 MAPK did not affect c-Src activity in PM
Jin et al., J Biol Chem 2008 (Cell Transformation, Neoplastic) : Suppression of c-Src by RNA interference in highly metastatic 4T1 mammary cancer cells, which express endogenous TrkC, resulted in markedly decreased expression of cyclin D1 and suppression of activation of Ras-Erk1/2 and PI3K-Akt
Yamaguchi et al., Brain Tumor Pathol 2005 (Astrocytoma) : Interestingly, ERK1/2 in U373 MG cells is also activated by several other mitogenic G protein coupled receptors ( GPCRs ) including alpha ( 1B ) -adrenergic, M ( 3 ) -muscarinic, and H ( 1 ) -histaminergic in an Src dependent manner
Slomiany et al., Inflammopharmacology 2008 : Our findings demonstrate that leptin protection of salivary gland acinar cells against ethanol cytotoxicity involves Src kinase mediated parallel activation of MAPK/ERK and Akt that result in up-regulation of the respective prostaglandin and nitric oxide synthase pathways
Eblin et al., Toxicology 2008 : To determine importance of ROS in the MAPK cascade and its downstream induction of p-Src and COX-2, specific ROS antioxidants ( both enzymatic and non-enzymatic ) were used concomitantly with arsenicals
Chaturvedi et al., Mol Cell Biochem 2008 : Src inhibition increased mitogen activated protein kinase phosphatase-1 protein and decreased phosphorylation of SF-1, which correlated with increased CYP17 promoter activity and mRNA levels
Holmström et al., Exp Cell Res 2008 (MAP Kinase Signaling System) : EGF stimulated Erk1/2 activation involved Src tyrosine kinases, but not PKC or PI3K, whereas in PDGF induced Erk1/2 activation, PI3K, PKC ( probably the atypical zeta isoform ) and Src were involved sequentially
Kim et al., Mol Cancer Res 2008 (MAP Kinase Signaling System...) : Inhibition of c-Src by pretreatment with Src family kinase inhibitor PP2 or small interfering RNA targeting of c-Src attenuated radiation induced p38 MAPK and Rac1 activation and enhanced Bax and Bak activation and cell death
Kim et al., Mol Cancer Res 2008 (MAP Kinase Signaling System...) : Inhibition of c-Src attenuated Rac1 and p38 MAPK activations and Ser ( 473 ) phosphorylation of Akt
Schweppe et al., J Clin Endocrinol Metab 2009 (Carcinoma...) : Phospho-ERK1/2 was not affected by AZD0530, indicating that Src signaling does not require MAPK
Chai et al., IUBMB Life 2009 : The current study investigated a possible role for p38 MAPK in the regulation of ( SRC ) -3 phosphorylation/degradation and in retinoic acid receptor (RAR)alpha signaling in mouse fetal cortical neurons treated with all-trans retinoic acid ( ATRA )
Meng et al., Br J Cancer 2009 (Adenocarcinoma...) : In addition, the Src inhibitor, PP2, blocked the phosphorylation of FAK, ERK1/2 , PI3K, and Akt
Feng et al., Oncogene 2009 (Carcinoma, Renal Cell...) : Strikingly, silencing of Cbp negatively affected the sustaining of Erk1/2 activation but not c-Src activation induced by serum
Watanabe et al., Mol Cancer Res 2009 (Sarcoma, Synovial) : Adaptor protein Crk induces Src dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation
Genua et al., Cancer Res 2009 (Prostatic Neoplasms) : CREB phosphorylation involved c-Src dependent extracellular signal regulated kinase 1/2 activation , but not protein kinase A, protein kinase C, or calmodulin dependent kinase II, and occurred also in cells transfected with AR or estrogen receptor mutants that do not localize into the nucleus
Hsieh et al., Neurotox Res 2010 : Taken together, these results suggested that in RBA-1 cells, activation of NF-kappaB by a c-Src dependent PI3K/Akt-p42/p44 MAPK activation mediated through transactivation of PDGFR is essential for MMP-9 gene upregulation induced by LTA
Zhang et al., Biochem Pharmacol 2010 (Breast Neoplasms...) : By contrast, S3I-201.1066 has no effect on Src activation or the EGFR mediated activation of the Erk1/2 ( MAPK ) pathway
Ronda et al., J Steroid Biochem Mol Biol 2010 : Role of estrogen receptors, PKC and Src in ERK2 and p38 MAPK signaling triggered by 17ß-estradiol in skeletal muscle cells
Dai et al., Blood 2011 (MAP Kinase Signaling System...) : The dual Src/Abl inhibitors BMS354825 and SKI-606 blocked Chk1-inhibitor induced extracellular signal regulated kinase 1/2 ( ERK1/2 ) activation, markedly increasing apoptosis in association with BimEL up-regulation, p34 ( cdc2 ) activation, and DNA damage in MM cell lines and primary CD138 ( + ) MM samples
Vallabhaneni et al., Breast Cancer Res Treat 2011 (Breast Neoplasms) : Depletion of Src using shRNA substantially reduced E2 mediated activation of Src and MAPK activation in resistant model cells
Rowlands et al., Hypertension 2011 : Treatment of cells with pertussis toxin or inhibition of GPR30/epidermal growth factor receptor kinase transactivation prevented equol induced activation of extracellular signal regulated kinase 1/2 via c-Src , Akt, and eNOS
Arpaia et al., Oncogene 2012 (Neoplasm Metastasis...) : Our data indicate that interaction between Cav1 and Rho-GTPases ( most likely RhoC but not RhoA ) promotes metastasis by stimulating a5-integrin expression and regulating the Src dependent activation of p130 ( Cas ) /Rac1, FAK/Pyk2 and Ras/Erk1/2 signaling cascades
Lei et al., Am J Physiol Lung Cell Mol Physiol 2011 : In summary, in adult rat AECs T3-stimulated Src kinase activity can activate both PI3K/Akt and MAPK/ERK1/2 , and activation of Akt is necessary for T3-induced Na-K-ATPase activity
Bhattacharjee et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Our data show that Src kinase activity regulates IL-13 induced p38 MAPK tyrosine phosphorylation via the upstream kinases MKK3 or MKK6
Duru et al., J Surg Res 2012 : Src inhibition with PP2 reduced p38 ( MAPK ) and JNK activation but did not alter ERK1/2 activation
Lopez et al., Cell Death Differ 2012 (MAP Kinase Signaling System...) : Importantly, in a set of human cancer cells with Src- , Kras- or BRAF dependent activation of Erk1/2 , resistances to staurosporine or thapsigargin were also shown to depend on Bik degradation rate via a similar mechanism
Liu et al., Mol Cell Biol 1998 (Cell Transformation, Neoplastic) : Expression of WT-PTP1B reduces formation of p130Cas-Crk complexes and inhibits mitogen activated protein kinase activation by Src and Crk