Gene interactions and pathways from curated databases and text-mining

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ESR1 — GTF2H3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of ESR1-GTF2H3 → estradiol/ESR1 complex (ESR1) (directlyIncreases)

    Evidence: In contrast, ligand-dependent S118 phosphorylation is mediated through the association of ERalpha with TFIIH and the cyclin-dependent kinase CDK7 [82,83].
  • OpenBEL Selventa BEL large corpus: ESR1 → Complex of ESR1-GTF2H3 (directlyIncreases, ESR1/GTF2H3 Activity)
    Evidence: In contrast, ligand-dependent S118 phosphorylation is mediated through the association of ERalpha with TFIIH and the cyclin-dependent kinase CDK7 [82,83].