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GJA1 — JUN
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Andersen et al., Environ Health Perspect 2000
(Leiomyoma...) :
However, estrogen did not
induce myometrial
cx43 gene transcription in vitro ; instead, it inhibited
AP-1 induction of cx43 expression ... Results from an examination of pregnancy myometrial tissue support the concept that
AP-1 activity is
involved in the induction of myometrial
cx43 expression at term and that suppression of ER-beta expression is needed for this induction
Petrich et al., Circ Res 2002
(Heart Failure) :
c-Jun N-terminal kinase activation
mediates downregulation of
connexin43 in cardiomyocytes
Ursitti et al., J Mol Cell Cardiol 2007
:
Decreases in the expression of connexin 43 and the integrity of gap junctions in cardiac muscle, induced by the constitutive activation of the c-Jun N-terminal kinase (JNK) signaling pathway, have been linked to conduction defects and sudden cardiac failure in mice [ Petrich BG, Gong X, Lerner DL, Wang X, Brown JH, Saffitz JE, Wang Y.
c-Jun N-terminal kinase activation
mediates downregulation of
connexin 43 in cardiomyocytes
Yan et al., Cardiovasc Res 2013
(Arrhythmias, Cardiac...) :
c-Jun N-terminal kinase activation
contributes to reduced
connexin43 and development of atrial arrhythmias