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CDK5 — MDM2
Text-mined interactions from Literome
Lee et al., J Cell Sci 2007
:
Cdk5 mediates disruption of the interaction between p53 and
Hdm2 ( also known as Mdm2 ), and prevents Hdm2 induced p53 ubiquitylation and downregulation
Bianchetta et al., J Neurosci 2011
:
Here we demonstrate that genetic or pharmacological reduction of
Cdk5 activity
increases the interaction of
Mdm2 with PSD-95 and enhances PSD-95 ubiquitination without affecting PSD-95 protein levels in vivo in mice, suggesting a nonproteolytic function of ubiquitinated PSD-95 at synapses ... This interaction is increased by genetic reduction of
Cdk5 activity or NMDA receptor stimulation and is
dependent on
Mdm2