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IL6 — VEGFA

Text-mined interactions from Literome

Gloddek et al., J Endocrinol 1999 : Pituitary adenylate cyclase activating polypeptide, interleukin-6 and glucocorticoids regulate the release of vascular endothelial growth factor in pituitary folliculostellate cells ... VEGF secretion was also stimulated by interleukin-6 (IL-6) whereas basal, IL-6- and PACAP stimulated secretion was inhibited by the synthetic glucocorticoid dexamethasone
Matsushita et al., Infect Immun 1999 : Prevotella intermedia LPS, phorbol 12-myristate 13-acetate, and interleukin-6 also induced VEGF mRNA expression in HPC
Funamoto et al., J Biol Chem 2000 : VEGF protein production and secretion to the medium were also enhanced by LIF and cardiotrophin-1 but not by interleukin-6
Tsuji et al., Biol Pharm Bull 2000 : Effects of sulfhydryl compounds on interleukin-1 induced vascular endothelial growth factor production in human synovial stromal cells
Wang et al., Biochem Biophys Res Commun 2001 (Arteriosclerosis) : VEGF increased intracellular reactive oxygen species ( ROS ), NF-kappaB activation and IL-6 expression ... Blockade of the generation of intracellular ROS by antioxidants inhibited VEGF induced NF-kappaB activation, IL-6 expression, and cell migration indicating that generation of ROS was required for NF-kappaB activation and the chemotactic activity of VEGF ... Further, IL-6 induced by VEGF is involved in the ability of the growth factor to stimulate migration
Stachon et al., Prostate 2001 (Prostatic Hyperplasia) : The IL-6 secretion of HPEC was stimulated by VEGF and TNF-alpha, but not by ATP and bradykinin
Gupta et al., Leukemia 2001 (Multiple Myeloma) : Addition of exogenous IL-6 ( 10 ng/ml ) increased VEGF secretion by BMSCs. Conversely, VEGF ( 100 ng/ml ) significantly increased IL-6 secretion by BMSCs ... Moreover, anti-human VEGF ( 1 microg/ml ) and anti-human IL-6 ( 10 microg/ml ) neutralizing antibodies reduced IL-6 and VEGF secretion, respectively, in cultures of BMSCs alone and co-cultures of BMSCs and MM cells
Benoy et al., Clin Breast Cancer 2002 (Breast Neoplasms...) : These results suggest a role for tumor derived IL-6 in regulating VEGF expression in platelets and their precursors and also confirm the role of circulating platelets in the storage of VEGF
Masui et al., Anticancer Res 2002 (Carcinoma, Pancreatic Ductal...) : IL-6 treatment induced VEGF expression significantly and dose-dependently in CFPAC-1 cells, while it did not change in AsPC-1 cells
Alexandrakis et al., Ann Hematol 2003 (Multiple Myeloma...) : IL-6 and tumor necrosis factor-alpha (TNF-alpha) are involved in the secretion of VEGF by IL-6r expressing myeloma cells
Wei et al., Oncogene 2003 (Neovascularization, Pathologic...) : Notably, pharmacological inhibition of PI3-K or MAPK failed to inhibit IL-6 mediated transcriptional upregulation of VEGF
Nakahara et al., Arthritis Rheum 2003 (Arthritis, Rheumatoid) : IL-6 is the pivotal cytokine that induces VEGF production in synergy with IL-1beta or TNFalpha, and this may be the mechanism by which IL-6 blockade effectively suppresses VEGF production in synovial fibroblasts
Penkowa et al., J Neurosci Res 2003 (Disease Models, Animal...) : Also, IL-6 induced significant increases in proinflammatory cytokines IL-1, IL-12, and tumor necrosis factor-alpha as well as growth factors basic fibroblast growth factor (bFGF), transforming growth factor-beta, neurotrophin-3, angiopoietin, vascular endothelial growth factor , and the receptor for bFGF
Funatsu et al., Ophthalmology 2003 (Diabetic Retinopathy...) : Interleukin-6 may possibly induce an increase of vascular permeability through a paracrine effect on VEGF in these subjects
Weiss et al., Cardiovasc Res 2003 (Myocarditis) : OSM, but not CT-1, IL-6 or LIF increased VEGF-1 production in human adult cardiac myocytes dose-dependently derived from five different donors
Gutsche et al., Mol Hum Reprod 2003 : Epithelial mRNA expression of IL-1beta, IL-6 and LIF increased by stimulation with TGF-beta1 and IL-8, but not with VEGF
Naruishi et al., Transplantation 2003 (Neovascularization, Pathologic) : C-jun N-terminal kinase ( JNK ) inhibitor, SP600125, blocks interleukin (IL)-6 induced vascular endothelial growth factor ( VEGF ) production : cyclosporine A partially mimics this inhibitory effect ... SP600125 significantly suppressed interleukin (IL)-6 induced production of VEGF in cultured fibroblasts
Omori et al., J Biol Chem 2004 : High glucose enhances interleukin-6 induced vascular endothelial growth factor 165 expression via activation of gp130 mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts ... Interestingly, HGFs increased IL-6/sIL-6R induced VEGF165 mRNA expression and VEGF165 secretion under the HG condition compared with levels under the NG condition
Giuliani et al., Leukemia 2004 (Multiple Myeloma...) : A significant inhibition of basal VEGF secretion by myeloma cells as well as a suppression of the stimulatory effect of IL-6 on VEGF was observed by either PD98059 or PD184352
Imagawa et al., Respiration 2004 (Sleep Apnea Syndromes...) : To assess the involvement of IL-6 and TNF-alpha in VEGF increases in patients with severe OSAHS, serum levels of IL-6 and TNF-alpha were determined in patients with severe OSAHS ( n=110 ) and compared to those of controls ( n=45 ) using an enzyme linked immunosorbent assay
Pufe et al., J Pathol 2004 (Osteoarthritis) : Furthermore, VEGF induced IL-1beta, IL-6 , TNF-alpha, and nitric oxide expression to a small extent and stimulated the proliferation of immortalized chondrocytes
Ilhan et al., World J Gastroenterol 2004 (Abdominal Pain...) : The levels of VEGF , CRP, PCT, IL-6, MDA and NO in cancer patients were significantly higher than those in healthy controls and the levels of CRP, PCT, IL-6 , MDA and NO were statistically increased in infection group when compared with non-infection group ( P < 0.001 )
Steiner et al., Eur J Cancer 2004 (Prostatic Neoplasms) : The stimulatory effect of IL-6 on VEGF production was abolished by an inhibitor of the signalling pathway for phosphoinositol 3 kinase in LNCaP-IL-6+ and LNCaP-IL-6- cells
Vannay et al., Exp Physiol 2004 (Acute Kidney Injury...) : As IL-6 mRNA expression increased simultaneously with VEGF protein levels, the post-ischaemic regulation of IL-6 and VEGF synthesis might be interrelated in rat kidney
Huang et al., J Biomed Sci 2004 (Neovascularization, Pathologic...) : Interleukin-6 increases vascular endothelial growth factor and angiogenesis in gastric carcinoma ... In this study, we attempted to clarify whether IL-6 can regulate VEGF and angiogenesis in GC
Inoue et al., Rheumatol Int 2005 (Osteoarthritis, Hip...) : Induction of vascular endothelial growth factor and matrix metalloproteinase-3 ( stromelysin ) by interleukin-1 in human articular chondrocytes and synoviocytes
Faffe et al., Am J Physiol Lung Cell Mol Physiol 2005 : Oncostatin M (OSM), but not other IL-6 family cytokines, increased VEGF release, and IL-1beta enhanced OSM induced VEGF release
Loeffler et al., Int J Cancer 2005 (Glioblastoma) : Interleukin-6 induces transcriptional activation of vascular endothelial growth factor ( VEGF ) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1 ... We have scrutinized the mechanism of transcriptional activation of vascular endothelial growth factor ( VEGF ) expression by IL-6 in the mouse brain and in glioblastoma cells ... We further show that IL-6 induced VEGF transcription and VEGF secretion by human glioblastoma cells is dependent on signal transducer and activator of transcription 3 ( STAT3 )
Culig et al., J Cell Biochem 2005 (MAP Kinase Signaling System...) : IL-6 is also involved in regulation of vascular endothelial growth factor expression as well as neuroendocrine differentiation in prostate
Zhang et al., Zhonghua Nei Ke Za Zhi 2005 (Multiple Myeloma) : Exogenous IL-6 stimulated VEGF secretion of BMSCs. Importantly, when U266 cell were adhered to BMSCs, there was significant increase of VEGF ( 2.5 - 5.0 fold, P < 0.05 ) and IL-6 ( 5.5 - 9.0 fold, P < 0.05 ) secretion ... The secretion of VEGF or IL-6 in BMSCs alone or co-cultures of BMSCs with U266 were inhibited by anti-human IL-6 or anti-human VEGF antibody
Yoo et al., J Immunol 2005 (Arthritis, Experimental) : Arginine-rich anti-vascular endothelial growth factor ( anti-VEGF ) hexapeptide inhibits collagen induced arthritis and VEGF stimulated productions of TNF-alpha and IL-6 by human monocytes ... In addition, VEGF directly increased the production of TNF-alpha and IL-6 from human PBMC ... Moreover, anti-VEGF dRK6 inhibited the VEGF induced production of TNF-alpha and IL-6 from synovial fluid mononuclear cells of RA patients and decreased serum IL-6 levels in CIA mice
Su et al., Cancer Res 2005 (Neoplasms...) : The in vitro analysis of antiangiogenic activity showed that S7 peptide substantially inhibits IL-6 induced vascular endothelial growth factor-A expression and angiogenesis in different cancer cell lines
Yokoyama et al., Oral Microbiol Immunol 2005 : Stimulation of HGF with VEGF resulted in production of IL-6 and IL-8 in a dose dependent manner
Wang et al., Cell Signal 2005 (MAP Kinase Signaling System...) : Differential activation of the MEK/ERK and PI3K/AKT pathways that result in differential secretion IL-6, IL-8, TIMP-2 and VEGF were seen contingent on the cell type examined ; VEGF and TIMP-2 expression in PC3 cells are dependent on AKT activation and ERK activation in LNCaP and LNCaP C4-2B cells leads to IL-6 or IL-8 secretion
Nolan et al., Inflammation 2004 (Disease Models, Animal...) : In vitro, VEGF stimulated IL-6 , IL-10 and reduced the inhibitory isoform of C/EBPbeta in cultured macrophages
Shin et al., Yonsei Med J 2005 : The objectives of this study were to explore whether ovarian vascular endothelial growth factor ( VEGF ) expression in mice can be regulated by IL-6 ( interleukin-6 ), angiotensin II, FSH, and hCG ; and to test whether the mouse ovarian VEGF expression can result in angiogenesis ... Treatment of mice ovaries with IL-6, FSH, and hCG resulted in a significant increase of VEGF mRNA, and IL-6 was the most potent inducer of VEGF
Yao et al., Biochem Biophys Res Commun 2006 : Pharmacological inhibitor of PI3K failed to inhibit IL-6 mediated VEGF overexpression, while blocking ERK1/2 with PD98059 could abolish IL-6 induced KDR overexpression
El-Obeid et al., Phytomedicine 2006 : On the protein level, melanin significantly induced TNF-alpha and IL-6 protein production and inhibited VEGF production by monocytes and PBMC
Adachi et al., Int J Cancer 2006 (Mesothelioma) : Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas ... In addition, IL-6/sIL-6R stimulation increased the expression of vascular endothelial growth factor ( VEGF ) in 4 out of 5 cell lines, and this induction was inhibited by MRA treatment ... The involvement of the signal transducer and activator of transcription 3 ( STAT3 ) pathway in both cell growth and VEGF induction by IL-6/sIL-6R was verified by dominant negative STAT3 transduction combined with adenovirus gene-delivery methods ... Although IL-6 induces VEGF through the JAK2/STAT3 pathway, anti-VEGF antibody could not inhibit the IL-6 induced cell growth observed in H2052 and H226
Yao et al., J Cereb Blood Flow Metab 2007 (Arteriovenous Malformations) : Further research revealed that IL-6 could stimulate SMC proliferation, VEGF release, and KDR activation in control HCSMCs
Ammit et al., Am J Physiol Lung Cell Mol Physiol 2007 (Asthma) : However, in the presence of sIL-6Ralpha, IL-6 increased eotaxin and VEGF release and may thereby contribute to local inflammation and vessel expansion in airway walls of asthmatic subjects
Kanazawa et al., Eur Arch Otorhinolaryngol 2007 (Carcinoma, Squamous Cell...) : IL-6 stimulation also induced the extracellular regulated protein kinase 1/2 activation and increased vascular endothelial growth factor release
Lee et al., Ann N Y Acad Sci 2007 : Role of vascular endothelial growth factor-D ( VEGF-D ) on IL-6 expression in cerulein stimulated pancreatic acinar cells
Rega et al., Arterioscler Thromb Vasc Biol 2007 : We used tissue explants as well as primary cultures of preadipocytes and adipocytes from human subcutaneous and visceral adipose tissue to investigate whether the gp130 ligands oncostatin M (OSM), interleukin-6 (IL-6) , leukemia inhibitory factor (LIF), and cardiotrophin-1 (CT-1) regulate VEGF expression in human adipose tissue ... In mice, IL-6 and OSM increased serum levels of VEGF and VEGF mRNA and vessel density in adipose tissue
Feurino et al., Cancer Biol Ther 2007 (MAP Kinase Signaling System...) : IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells
Chen et al., Microcirculation 2008 (Dermatitis, Atopic...) : IL-6 and IFN-gamma stimulated VEGF-A mRNA production in the skin and in primary keratinocytes of transgenic mice ... In conclusion, IL-6 and IFN-gamma may play important roles in upregulation of VEGF-A , along with other pro-angiogenic factors, to induce dermal microvascular angiogenesis
Beldi et al., Gastroenterology 2008 (Disease Models, Animal) : The effects of extracellular ATP on vascular endothelial growth factor ( VEGF ), hepatocyte growth factor (HGF), and interleukin-6 responses were determined in vivo and in vitro
Hao et al., Am J Physiol Cell Physiol 2009 : By using a cytokine antibody array that detects the end point protein products released from endothelial cells ( ECs ), we found that VEGF , via VEGF receptor 2 (VEGFR2), predominantly induced the production of proinflammatory cytokine interleukin (IL)-6 and CXC chemokines IL-8 and growth related oncogene-alpha ( GRO-alpha ) in ECs but not in leukocytes among 36 cytokines in the array ... Importantly, the VEGF induced production of IL-6 , IL-8, and GRO-alpha was inhibited approximately 70 %, 40 %, or 37 % by PKD1 silencing ( more than 90 % knockdown ) with three small interference RNAs that target different PKD1 regions ... Our results indicate that VEGF , via VEGFR2-PKD1 axis, induces the production of proinflammatory cytokine IL-6 , IL-8, and GRO-alpha in ECs but not in leukocytes, which may offer new insights into the mechanism of the proinflammatory activity of VEGF
Xiong et al., J Biol Chem 2009 : This is in good contrast to VEGF stimulated interleukin-6 release from endothelium, which is selectively mediated through VEGFR1
Rojas et al., Invest Ophthalmol Vis Sci 2010 (Leukostasis...) : The results indicate that IL-6 expression is essential for angiotensin II-induced increases in retinal VEGF expression, leukostasis, and vascular remodeling
Schmeding et al., Transplantation 2010 (Fatty Liver) : Analysis of liver enzymes, histology ( hematoxylin-eosin and periodic acid Schiff stain ), immunostaining ( terminal deoxynucleotide transferase- mediated dUTP nick-end labeling, hypoxyprobe, and tumor necrosis factor-alpha ), and reverse transcriptase-polymerase chain reaction of cytokine messenger RNA ( interleukin-1 , interleukin-6, hypoxia induced factor-1 alpha, vascular endothelial growth factor , and hepatocyte growth factor ) were performed at defined time points ( 2, 4.5, 24, 48 hr, and 7 days postoperatively )
Huang et al., J Exp Clin Cancer Res 2010 (Pancreatic Neoplasms) : IL-6 remarkably promoted the growth of Capan-2 cells ( P < 0.05 ), and VEGF and MMP-2 mRNA and protein expression were increased significantly
Lee et al., Inflammation 2011 (Breast Neoplasms...) : Expression of interleukin (IL)-6 , IL-8, and tumor necrosis factor-a were substantially increased and involved in macrophage induced VEGF and MMP-9 mRNA expression in MCF-7 cells
Chew et al., BMC cancer 2010 (Nasopharyngeal Neoplasms...) : The present study examined the roles of EBV latent membrane protein-1 (LMP1), interleukin-6 (IL-6), interleukin-10 (IL-10), transforming growth factor-beta 1 ( TGF-ß1 ) and laminin in the regulation of matrix-metalloproteinases ( MMPs ) and vascular endothelial growth factor ( VEGF ) in NPC
Choe et al., Joint Bone Spine 2012 (Arthritis, Rheumatoid...) : Tacrolimus ( FK506 ) inhibits interleukin-1ß induced angiopoietin-1, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes
Zhu et al., World J Gastroenterol 2011 (Stomach Neoplasms) : ( - ) -Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer ... IL-6 also increased VEGF mRNA expression by 3.1 folds ... However, PD98059 and LY294002 did not change VEGF expression induced by IL-6 ... EGCG inhibits IL-6 induced VEGF expression and angiogenesis via suppressing Stat3 activity in gastric cancer, which has provided a novel mechanistic insight into the anti-angiogenic activity of EGCG
Boreddy et al., PloS one 2011 (Neoplasm Invasiveness...) : STAT-3 over-expression or IL-6 treatment significantly induced HIF-1a and VEGF expression ; however, BITC substantially suppressed STAT-3 as well as STAT-3 induced HIF-1a and VEGF expression
Hao et al., Am J Physiol Cell Physiol 2012 : Lastly, the VEGF induced signal transduction and the production of interleukin (IL)-6 were significantly enhanced by PTP-MEG2 knockdown in ECs, whereas the VEGF induced IL-6 production was inhibited 50 % by PTP-MEG2 overexpression
Ahmad et al., Carcinogenesis 2012 (Neoplasm Invasiveness) : We also observed an inhibitory effect of garcinol on IL-6 induced STAT-3 phosphorylation and production of urokinase-type plasminogen activator, vascular endothelial growth factor and matrix metalloproteinase-9, which might explain the reduced invasion and aggressiveness of cells treated with garcinol
Gao et al., Ann Rheum Dis 2013 (Arthritis, Psoriatic...) : Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6 , IL-8, MMP2 and 9 expressions in RA synovial explants
Tzeng et al., Biochem Pharmacol 2013 (Bone Neoplasms...) : Interleukin-6 induces vascular endothelial growth factor expression and promotes angiogenesis through apoptosis signal regulating kinase 1 in human osteosarcoma ... Pretreatment of cells with IL-6R antibody reduced IL-6 mediated VEGF production ... The apoptosis signal regulating kinase 1 ( ASK1 ) /p38/AP-1 pathway was activated after IL-6 treatment, and IL-6 induced VEGF expression was abolished by the specific inhibitor and siRNA of ASK1, p38, and AP-1 cascades ... Importantly, knockdown IL-6 reduced VEGF expression and abolished osteosarcoma conditional medium mediated angiogenesis
Nguyen et al., Biomed Res 2012 (Inflammation) : Results showed that exogenous VEGF upregulates expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-a mRNAs, whereas VEGF blocker partially diminishes the LPS induced expression of pro-inflammatory factors compared to the positive control group
Wei et al., J Clin Endocrinol Metab 2013 (Disease Models, Animal...) : With activation of signal transducer and activator of transcription 3 ( STAT3 ) and ERK, Hyper IL-6 increased vascular endothelial growth factor expression and the vascular permeability of ECs
Jiang et al., Ann Clin Lab Sci 2013 (Diabetes Mellitus, Type 2) : Conclusions Our data demonstrate that HIF-1a and IL-6 could regulate VEGF expression, and that higher levels of HIF-1a, IL-6, and VEGF may contribute to the pathogenesis of diabetic micro-angiopathy
Ben-Av et al., FEBS Lett 1995 (Arthritis, Rheumatoid...) : Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1 : a potential mechanism for inflammatory angiogenesis
Cohen et al., J Biol Chem 1996 : Interleukin 6 induces the expression of vascular endothelial growth factor
Kvanta et al., Curr Eye Res 1995 : Both interleukin-1 and transforming growth factor beta induced VEGF expression in choroidal fibroblasts although with different time courses ... By using Western blotting, it was further found that stimulation with interleukin-1 induced VEGF protein expression in choroidal fibroblasts but not in RPE cells