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IL6 — PRKAG1

Text-mined interactions from Literome

MacDonald et al., J Appl Physiol 2003 : The present data are compatible with a role for AMPK in IL-6 release during exercise or a role for IL-6 in activating AMPK
Giri et al., J Neurosci 2004 (Inflammation) : A pharmacological activator of AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR ) inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha, interleukin-1beta , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages ... A pharmacological activator of AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR ) inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha, interleukin-1beta, and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages
Kelly et al., Biochem Biophys Res Commun 2004 : The results indicate that IL-6 can activate AMPK in muscle and adipose tissue, and that this contributes to, but does not fully account for, the increase in AMPK activity in these tissues in response to exercise
Du et al., Biochem Biophys Res Commun 2005 : To determine whether AMPK activation will promote IL-6 production, cardiac fibroblasts ( CFs ) from mice were incubated with AMPK activator, 5-aminoimidazole-4-carboxamide-1-4-ribofuranoside ( AICAR ) ... In conclusion, AMPK activation promoted IL-6 production in CFs via p38 MAPK dependent pathway
Carey et al., Diabetes 2006 (Hyperinsulinism) : Furthermore, IL-6 rapidly and markedly increased AMP activated protein kinase (AMPK)
Weigert et al., Am J Physiol Cell Physiol 2007 : Because IL-6 has been shown to activate AMP activated kinase (AMPK), we studied whether, in turn, activated AMPK induces IL-6 expression
Baumann et al., Exp Cell Res 2007 (Multiple Myeloma) : Activation of AMPK inhibited basal extracellular signal regulated kinase ( ERK ), mammalian target of rapamycin (mTOR) and P70S6 kinase ( P70S6K ) as well as AKT phosphorylation, and blocked IL-6 , IGF-1, and HS-5 stromal cell conditioned medium induced increase of cell growth
Pedersen et al., Biochem Soc Trans 2007 (Disease...) : Furthermore, IL-6 rapidly and markedly increases AMPK ( AMP activated protein kinase ) and the metabolic effects of IL-6 were abrogated in AMPK dominant negative infected cells
Yuen et al., Diabetes 2009 : The effect of IL-6 with and without insulin on AMPK , insulin, and eNOS signaling in and nitric oxide ( NO ) release from human aortic endothelial cells ( HAECs ) was examined ... IL-6 blunted increases in insulin signaling, eNOS phosphorylation ( Ser1177 ), and NO production and reduced phosphorylation of AMPK in HAEC in vitro and capillary recruitment in vivo
Kelly et al., Diabetes 2009 : Interleukin-6 (IL-6) directly activates AMP activated protein kinase (AMPK) in vivo and in vitro ; however, the mechanism by which it does so is unknown ... AMPK activation by IL-6 coincided temporally with a nearly threefold increase in the AMP : ATP ratio in the EDL ... The effects of IL-6 on both AMPK activity and energy state were inhibited by coincubation with propranolol, suggesting involvement of beta-adrenergic signaling ... In keeping with this notion, IL-6 concurrently induced a transient increase in cAMP, and its ability to activate AMPK was blocked by the adenyl cyclase inhibitor 2'5'-dideoxyadenosine
Łabuzek et al., Neurotoxicology 2010 : Furthermore, we found that the effects of AICAR on IL-6 and TNF-alpha ( 12, 24h ) release and on the expression of iNOS and NF-kappaB p65 are not AMPK dependent because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR
Fan et al., J Cell Physiol 2011 : Inhibitors of AMPK ( araA ), p38MAPK ( SB202190 ), and ERK1/2 ( PD98059 and U0126 ) but not JNK ( SP600125 ) suppressed gAd induced IL-6 production
Łabuzek et al., Pharmacol Rep 2010 : Furthermore, the effects of metformin on the release of IL-1ß, IL-6 , IL-10, TGF-ß, NO, and ROS as well as on the expression of arginase I, iNOS, NF-?B p65 and PGC-1a were not AMPK dependent , because pretreatment of LPS activated microglia with compound C, a pharmacological inhibitor of AMPK, did not reverse the effect of metformin
Adser et al., Acta Physiol (Oxf) 2011 : The aim of this study was to test the hypothesis that interleukin (IL)-6 plays a role in exercise induced peroxisome proliferator activated receptor ? co-activator ( PGC ) -1a and tumor necrosis factor (TNF)-a mRNA responses in skeletal muscle and to examine the potential IL-6 mediated AMP activated protein kinase (AMPK) regulation in these responses ... In conclusion, IL-6 affects exercise induced glycogen use, AMPK signalling and TNF-a mRNA responses in mouse skeletal muscle
Li et al., Basic Res Cardiol 2011 : AMPK activation by IL-6 appears to be dispensable for the mitochondrial biogenic responses to chronic treadmill exercise
Kato et al., Life Sci 2012 : In the present study, we investigated the involvement of AMP activated protein kinase (AMPK) , a regulator of energy metabolism, in the PDGF-BB stimulated IL-6 synthesis in MC3T3-E1 cells ... These results strongly suggest that AMPK positively regulates PDGF-BB stimulated IL-6 synthesis via the MAP kinases in osteoblasts
Serrano-Marco et al., Diabetologia 2012 (Insulin Resistance) : Furthermore, drug treatment prevented the IL-6 dependent reduction in phosphorylated AMP activated protein kinase (AMPK) , a kinase reported to inhibit STAT3 phosphorylation on Tyr7°5
Fitzgerald et al., PloS one 2012 (Carcinoma, Renal Cell...) : Finally, we have characterized that enhanced levels of IL-6 and IL-8 result in RCC cell invasion and that activation of AMPK reduces Nox4 expression, IL-6 and IL-8 production, and RCC cell invasion
Kato et al., Cell Signal 2012 : In the present study, we investigated the role of AMPK in the interleukin-1 (IL-1) stimulated IL-6 synthesis in osteoblast-like MC3T3-E1 cells ... These results strongly suggest that AMPK negatively regulates IL-1 stimulated IL-6 synthesis through the I?B/NF-?B pathway in osteoblasts
Tokuda et al., J Mol Endocrinol 2012 : In this study, we investigated the involvement of AMP activated protein kinase (AMPK) , a regulator of energy metabolism, in thrombin stimulated IL6 synthesis in MC3T3-E1 cells ... These results strongly suggest that AMPK regulates thrombin stimulated IL6 synthesis via p44/p42 MAP kinase and p38 MAP kinase in osteoblasts
Wan et al., PloS one 2012 : The activation of AMPK by IL-6 was independent of increases in lipolysis
Wan et al., PloS one 2012 (Insulin Resistance) : We have shown that IL-6 activates AMPK , a mediator of mitochondrial biogenesis, in adipose tissue ; however, IL-6 ( -/- ) mice fed a high fat diet have been reported to develop insulin resistance
White et al., Am J Physiol Endocrinol Metab 2013 (Cachexia...) : IL-6 suppression of mTOR activity was dependent on AMPK activation and independent of STAT signaling in myotubes
Kondo et al., Arch Biochem Biophys 2013 : We previously reported that interleukin 1 (IL-1) stimulates the synthesis of interleukin 6 (IL-6) through activation of ERK and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that AMP activated protein kinase (AMPK) negatively regulates the IL-1 induced IL-6 synthesis through I?B/NF-?B pathway
Nerstedt et al., Mol Cell Endocrinol 2013 : Further studies using the human hepatocellular carcinoma cell line HepG2 suggest that AMPK inhibits IL-6 signalling by repressing IL-6 stimulated phosphorylation of several downstream components of the pathway such as Janus kinase 1 (JAK1), SH2-domain containing protein tyrosine phosphatase 2 ( SHP2 ) and signal transducer and activator of transcription 3 ( STAT3 )
Kuroyanagi et al., Biochimie 2013 : We previously reported that interleukin-1 (IL-1), a potent bone resorptive cytokine, stimulates the synthesis of interleukin-6 (IL-6) via activation of p44/p42 mitogen activated protein ( MAP ) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that AMP activated protein kinase (AMPK) negatively regulates the IL-1 induced IL-6 synthesis through the inhibitor of ?B ( I?B ) /nuclear factor-?B ( NF-?B ) pathway