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IL6 — LYN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: LYN → IL6 (increases, IL6 Activity)
  Evidence: We demonstrate that IL-6 induces the phosphorylation of the C-terminal tyrosine residue of the HGAL protein via the Lyn kinase, and promotes its relocalization from the cytoplasm to podosome-like structures.
• OpenBEL Selventa BEL large corpus: LYN → IL6 (increases) Li et al., Blood 2005*
  Evidence: Lyn Tyr507 phosphorylation was quickly decreased and Tyr396 phosphorylation was increased even 0.5 minute after IL-6 treatment, consistent with the translocation of CD45RO to lipid rafts.
• OpenBEL Selventa BEL large corpus: LYN → IL6 (decreases) Li et al., Blood 2005*
  Evidence: Lyn Tyr507 phosphorylation was quickly decreased and Tyr396 phosphorylation was increased even 0.5 minute after IL-6 treatment, consistent with the translocation of CD45RO to lipid rafts.

Text-mined interactions from Literome

Zhou et al., Int J Hematol 2004 (Multiple Myeloma) : Additionally, IL-6 induced Lyn kinase activity in CD45+ U266 cells was increased by the cross linking of CD45, and this increase was due to the dephosphorylation of Tyr507 at Lyn
Hausherr et al., Oncogene 2007 (Multiple Myeloma) : IL-6-treatment of INA-6 cells induced the kinase activities of Fyn, Lyn and Hck, but not Src, and the IL-6 induced SFK activities were inhibited by peptide 18AD
Hallek et al., Exp Hematol 1997 : IL-6 induced the activation and tyrosine phosphorylation of p59Fyn, p56/59Hck, and p56Lyn ... Together, these results show for the first time that several Src kinases may become activated by IL-6 ( p59Fyn, p56/59Hck, and p56Lyn ) and associate with gp130 ( p56/59Hck and p56Lyn )