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SCNN1A — SGK1

Pathways - manually collected, often from reviews:

• Reactome Reaction: SCNN1A → SGK1 (reaction) Farr et al., Biochem J 2000, Staub et al., Kidney Int 2000, Soundararajan et al., Proc Natl Acad Sci U S A 2009, Heise et al., J Biol Chem 2010

Text-mined interactions from Literome

Snyder et al., J Biol Chem 2002 : SGK phosphorylated hNedd4-2 ( but not hNedd4 ), altering hNedd4-2 function ; phosphorylation reduced the binding of hNedd4-2 to alphaENaC , and hence, the hNedd4-2 mediated inhibition of Na+ absorption
Vasquez et al., J Cell Physiol 2008 : Increased alpha-ENaC levels and function are partly dependent upon the early induction of SGK1 expression
McTavish et al., Biochem J 2009 : The role of SGK1 ( serum- and glucocorticoid induced protein kinase 1 ) in the glucocorticoid induction of alpha-ENaC ( epithelial Na+ channel alpha subunit ) gene transcription was explored by monitoring the transcriptional activity of a luciferase linked, alpha-ENaC reporter gene construct ( pGL3-KR1 ) expressed in H441 airway epithelial cells