Gene interactions and pathways from curated databases and text-mining

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IL8 — VIP

Text-mined interactions from Literome

Delgado et al., J Biol Chem 1999 : We showed previously that VIP and PACAP inhibit the production of macrophage derived tumor necrosis factor-alpha, interleukin (IL)-6 , nitric oxide, and IL-12
Delgado et al., Biochem Biophys Res Commun 2003 : The present study reports the effect of VIP on IL-8 production by stimulated human monocytes ... VIP inhibits IL-8 production in a dose- and time dependent manner at the mRNA level
Delgado et al., Biochem Biophys Res Commun 2003 (Inflammation) : The present study reports the effect of VIP on IL-8 production by stimulated human THP1 monocytes ... VIP inhibits IL-8 production in a dose- and time dependent manner at the mRNA level
Toumi et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System) : In the human colonic epithelial cell line HT29-Cl.16E, VIP stimulates IL-8 secretion dose-dependently and IL-8 mRNA level at 10 ( -9 ) M ... However, inhibition of the ERK1/2 and p38 MAPK pathways reduced the VIP stimulated IL-8 secretion and mRNA level ... Together, our results showed that VIP stimulates IL-8 production in intestinal epithelial cells via PKA independent and MAPK dependent pathways
Dallos et al., Neuropeptides 2006 (Inflammation) : The aims of this study were a systematic investigation of the effects of the neuropeptides substance P ( SP ), calcitonin gene related peptide (CGRP), vasoactive intestinal polypeptide (VIP) and galanin (GAL) on the inflammatory cytokine production ( IL-1alpha, IL-8 and TNF-alpha ) of the keratinocytes, and a study of their role in the production and secretion of nerve growth factor (NGF) and its precursor molecule ( proNGF )
Kulka et al., Immunology 2008 : While anti-IgE stimulation did not induce significant production of chemokines, stimulation with VIP , SP or compound 48/80 potently induced production of monocyte chemoattractant protein-1, inducible protein-10, monokine induced by interferon-gamma ( MIG ), RANTES ( regulated on activation, normal, T-cell expressed, and secreted ) and IL-8
Hernanz et al., J Neuroimmunol 1996 : Differential effects of gastrin releasing peptide, neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects
Mullol et al., Neuropeptides 1997 : Vasoactive intestinal peptide (VIP) induces IL-6 and IL-8 , but not G-CSF and GM-CSF release from a human bronchial epithelial cell line ... We investigated the effect of VIP on the secretion of IL-6, IL-8 , GM-CSF, and G-CSF from a bronchial epithelial cell line ( BEAS 2B )