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IL3 — MYC
Text-mined interactions from Literome
Asao et al., J Biol Chem 2000
:
Interestingly, both
IL-3 and IFN-gamma
induce expression of the
c-Myc gene that is not dependent on the Stat1 activity
Kobayashi et al., Blood 2003
(Leukemia) :
To investigate the roles of c-myc during hematopoietic proliferation induced by growth factors, we used factor dependent human leukemic cell lines ( MO7e and F36P ) in which proliferation, cell cycle progression, and
c-Myc expression were strictly
regulated by granulocyte-macrophage colony stimulating factor ( GM-CSF ) and
interleukin-3 (IL-3) ... In these cell lines, both c-myc mRNA and
c-Myc protein stability were not
affected by GM-CSF and
IL-3 , suggesting a regulation of c-Myc protein at the translational level
Shi et al., J Immunol 1997
:
In the presence or the absence of serum, IL-2 and
IL-3 induced expression of both
c-Myc and Bax