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IL4 — PI3

Text-mined interactions from Literome

Hirasawa et al., Biochim Biophys Acta 2000 : These findings suggest that the activation of PI3-kinase and p38 MAPK is partially responsible for the antigen induced IL-4 production in RBL-2H3 cells
Feito et al., Eur J Immunol 2003 (MAP Kinase Signaling System) : The association of phosphoinositide 3-kinase (PI-3K) to H4/ICOS was enhanced by H4/ICOS cross linking, and PI-3K inhibitors inhibited ERK and JNK activation and IL-4/IL-10 secretion, but not p38 MAP kinase or ZAP-70 activation
Thieu et al., J Leukoc Biol 2007 : IL-4 induced NF-kappaB p52 production requires PI-3K activity and correlates with IkappaB kinase phosphorylation and TNF receptor associated factor 3 degradation
Isakoff et al., Proc Natl Acad Sci U S A 1995 : Although PDGF and IL-4 can activate PI3-kinase in the respective cell lines, they do not possess insulin 's ability to stimulate glucose uptake and GLUT4 translocation to the plasma membrane ... To investigate the role of PI3-kinase and IRS-1 in insulin stimulated glucose uptake we examined whether stimulation of insulin-sensitive cells with platelet derived growth factor ( PDGF ) or with interleukin 4 (IL-4) stimulates glucose uptake ; the activated PDGF receptor (PDGFR) directly binds and activates PI3-kinase, whereas the IL-4 receptor (IL-4R) activates PI3-kinase via IRS-1 or the IRS-1 related molecule 4PS
Gold et al., J Biol Chem 1994 : We show that interleukin-3 (IL-3), interleukin-4 (IL-4) , interleukin-5 (IL-5), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and steel factor ( SLF ) all activate PI 3-kinase
Izuhara et al., J Biol Chem 1993 : These data indicate that IL-4 induces activation of tyrosine kinase and also induces association between IL-4R and PI 3-kinase