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IRF6 — PLAU

Text-mined interactions from Literome

Ogura et al., J Periodontol 1999 (Periodontal Diseases) : LPS increased the protein and mRNA levels of both uPA and uPAR in gingival fibroblasts
Ohta et al., Thromb Res 2000 (Prostatic Neoplasms) : We examined the effects of LPS on uPA expression in human PC-3 prostatic cancer cells that express uPA in a conditioned medium ... LPS increased the uPA accumulation in PC-3 cells, whereas IL-1, IL-6, and TNFalpha did not ... A protein synthesis inhibitor, cycloheximide, amplified the LPS induced uPA mRNA, suggesting that LPS induces uPA by activating the gene expression in which de novo protein synthesis is not necessary
Kiguchi et al., Int J Cancer 2001 (Lung Neoplasms...) : We previously reported that both IL-1beta and LPS induce uPA in RC-K8 human lymphoma cells
Wang et al., J Immunol 2006 (Inflammation...) : Administration of anti-kringle Abs diminished LPS induced up-regulation of uPA and uPA KD in the lungs, and also decreased the severity of LPS induced acute lung injury, as determined by development of lung edema, pulmonary neutrophil accumulation, histology, and lung IL-6, MIP-2, and TNF-alpha cytokine levels
Cheng et al., Mol Cell Biochem 2009 : Evidences suggest that lipopolysaccharide (LPS) participates in the inflammatory response in the cardiovascular system ; however, it is unknown if LPS is sufficient to upregulate expressions and/or activity of uPA , tPA, MMP-2, and MMP-9 in myocardial cells ... In this study, we treated H9c2 cardiomyoblasts with LPS to explore whether LPS upregulates uPA , tPA, MMP-2, and MMP-9, and further to identify the precise molecular and cellular mechanisms behind this upregulatory responses ... Collectively, these results suggest that LPS upregulates the expression and/or activity of uPA , MMP-2, and MMP-9 through ERK1/2 signaling pathway in H9c2 cardiomyoblasts
Eggesbø et al., Thromb Res 1995 (Hyperlipoproteinemias...) : Upon stimulation with LPS , PCA and released PAI-2 increased sharply, while PA and released uPA declined
Niiya et al., Thromb Haemost 1995 (Lymphoma, B-Cell...) : Recombinant IL-1 alpha, recombinant IL-1 beta and LPS but not recombinant IL-6, recombinant TNF alpha and TGF beta dose-dependently increased uPA accumulation in the conditioned medium ... In contrast, both antibodies did not prevent LPS induced uPA gene expression ... These results suggest that both IL-1 alpha and IL-1 beta cause a rapid activation of uPA gene transcription in which de novo protein synthesis is not required and that LPS induces uPA gene expression independently of the IL-1 pathway