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CRH — IRF6

Text-mined interactions from Literome

Dent et al., Brain Res Dev Brain Res 1999 : Outside the SHRP, LPS resulted in an increase in CRH gene expression relative to saline injected controls
Grinevich et al., J Neuroendocrinol 2001 : In contrast, type 1 CRH receptor ( CRH-R1 ) mRNA responses to both LPS and restraint were blunted in R-LPS
Xia et al., J Neuroimmunol 2001 (Bacterial Infections...) : In the hypothalamic paraventricular nucleus, a major neuroendocrine and autonomic center, gamma ( 2 ) -MSH inhibits LPS induced increases in CRF mRNA levels, but does not suppress LPS augmented arginine vasopressin heteronuclear RNA expression
Wei et al., J Neuroimmunol 2002 (Inflammation) : However, LPS induced AVP release and ACh evoked CRH secretion in LEW/N were comparable with those of F344/N
Seo et al., Alcohol Clin Exp Res 2004 (Endotoxemia) : In the present work, we tested the hypothesis that alcohol decreased signals that are elicited by LPS and that stimulate hypothalamic CRF and VP synthesis, namely nitric oxide ( NO ) and the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6)
Singh et al., Toxicology 2004 : This study showed that peripheral LPS sequentially increased IL-1beta and iNOS mRNA levels, NO2 level, and CRF mRNA level in the hypothalamic PVN, and corticosterone concentration in blood
Fekete et al., Endocrinology 2005 (Body Weight) : These studies confirm an important role of ascending brainstem projections in LPS induced activation of CRH gene expression, but indicate that they do not mediate the effect of LPS to inhibit hypophysiotropic TRH gene expression
Li et al., J Neuroendocrinol 2006 (Hypoglycemia) : These results suggest that hypoglycaemia and LPS stress induced LH suppression involves activation of CRF ( 2 ) while restraint stress induced inhibition of LH pulses involves both CRF ( 1 ) and CRF ( 2 )
Crane et al., Neurosci Lett 2007 : Using Fos protein as a marker of neuronal activation, we found that systemic administration of PMX53 reduced the LPS induced activation of paraventricular corticotropin releasing factor ( PVN CRF ) and central amygdala cells
Singru et al., Endocrinology 2008 : Intracerebroventricular administration of the MAPK inhibitor, PD98059, prevented LPS induced ERK1/2 phosphorylation, c-fos activation, and the increase of CRH gene expression in the PVN but had no effect on c-fos activation in brainstem A2-C1/C2 regions
Menon et al., Reprod Sci 2008 (Obstetric Labor, Premature) : The objective of this study is to document differences in corticotrophin releasing hormone (CRH) , CRH receptor 1 (CRHR1), and CRH binding protein (CRHBP) gene expression in fetal membranes derived from African Americans and Caucasians in vitro in response to lipopolysaccharide (LPS) stimulation and to assess racial disparity in CRH concentrations in the amniotic fluid ( AF ) of women with spontaneous preterm birth (PTB) ... Between races, LPS significantly increased CRH and CRHR1 expression in African Americans and CRHBP in Caucasians, with no differences in controls
Sánchez-Lemus et al., Brain Behav Immun 2009 (Inflammation) : The ARB did not affect LPS induced TNF-alpha and IL-1beta gene expression, IL-6 or IL-1beta protein content or LPS induced decrease of CRF ( 1 ) receptors
Yuan et al., Peptides 2010 : LPS increased significantly CRF immunoreactivity in the submucosal and myenteric plexuses of proximal and distal colon compared to saline groups
Goebel et al., Neuroendocrinology 2011 : Intraperitoneal LPS induces a delayed rise in plasma CRH levels associated with an elevation in ACTH plasma levels 30 min later, suggesting that under conditions of immune challenge, CRH of peripheral origin may also contribute to pituitary activation, as detected using the RAPID method of blood processing, which improves CRH recovery
Rorato et al., Exp Physiol 2011 (Endotoxemia...) : This study investigated the effects of CCK ( 1 ) receptor blockade on lipopolysaccharide (LPS) induced hypophagia and hypothalamic CRF neuronal activation ... Devazepide pretreatment partly reversed LPS induced hypophagia and Fos-CRF and brainstem neuronal activation
Wang et al., Mol Cell Biochem 2012 (MAP Kinase Signaling System) : Furthermore, LPS induced CRH expression was inhibited by pretreatment with PD98059, a specific MAP kinase inhibitor, in a dose dependent fashion in which the mRNA and protein levels of CRH was decreased by 90 % and 95 %, respectively ... Altogether, these results demonstrate that LPS significantly upregulates CRH expression through MAP kinase signaling pathway in rat peritoneal macrophages
Rorato et al., Neuropharmacology 2012 (Body Weight...) : Rimonabant pretreatment potentiated LPS induced hypophagia, body weight loss and Fos-CRF and Fos-TH expressing neurons
Rivier et al., Stress 2001 : These data also illustrate the ability of a CRF antagonist or CRF antibodies to significantly augment IL-6 secretion, which indicates an inhibitory influence of the endogenous peptide in the paradigm we used.As comparable findings were obtained in adrenal-intact and adrenalectomized rats, they suggest that endogenous CRF is involved in the IL-6 response to LPS independently of circulating corticosteroids or other adrenal factors
Kakucska et al., Endocrinology 1993 : These studies demonstrate that LPS stimulates hypothalamic CRH by a mechanism that involves the action of IL-1 within the central nervous system and may proceed independently of peripheral actions of IL-1 circulating in the bloodstream