Gene interactions and pathways from curated databases and text-mining

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EPHB2 — WDR61

Text-mined interactions from Literome

Ahamed et al., J Biol Chem 2002 (MAP Kinase Signaling System) : In contrast, these inhibitors almost completely blocked both PAF induced ERK phosphorylation and LTC ( 4 ) generation in PAFR cells ... However, in mPAFR cells pertussis toxin only partially inhibited PAF induced ERK phosphorylation ... A Ca ( 2+ ) /calmodulin inhibitor had no effect on PAF induced ERK phosphorylation in PAFR cells but completely blocked the response in mPAFR cells
Wang et al., Oncogene 2003 (Carcinoma...) : PAF activated three prominent mitogen activated protein kinase modules ( ERK , p38MAPK and Jun N-terminal kinases ) in these cells, inhibited proliferation and induced differentiation ( measured by the induction of Waf1/p21 and the induction of the differentiation related marker CEA )
Khreiss et al., Cell Signal 2004 (Inflammation) : These results indicate that PAF induced activation of ERK contributes to both the expression of the pro-adhesive phenotype and repression of neutrophil apoptosis, thereby amplifying the inflammatory response
Zhou et al., Am J Physiol Heart Circ Physiol 2007 : PAF also stimulated activation of both ERK and p38 but not c-Jun NH ( 2 ) terminal kinase ( JNK ) mitogen activated protein ( MAP ) kinase pathways
Dorado et al., Nephrol Dial Transplant 2008 : In cultured human mesangial cells, Erk5 was activated by foetal calf serum ( FCS ), high glucose, endothelin-1, platelet activating factor (PAF) , epidermal growth factor (EGF) and transforming growth factor beta-1 ( TGF-beta1 )
Kim et al., Eur J Cancer 2012 (Lung Neoplasms...) : ERK , JNK, and p38 MAPKs were activated rapidly by PAF in the lungs, and the PAF induced metastasis of B16F10 was inhibited in a dose dependent manner by pretreatment with either U0126 ( ERK inhibitor ), SP600125 ( JNK inhibitor ), or SB202190 ( p38 inhibitor )
Hirabayashi et al., Biochem Biophys Res Commun 1998 : Stimulation of platelet activating factor (PAF) receptor induces activation of extracellular signal regulated kinase ( ERK ) and cytosolic phospholipase A2 (cPLA2) and release of arachidonic acid in Chinese hamster ovary cells
Zhang et al., J Biol Chem 1999 : The PAF induced p38 and ERK pathways appeared to be preferentially regulated by RGS16 and RGS1, respectively