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AREG — EPHB2
Text-mined interactions from Literome
Göoz et al., J Biol Chem 2006
:
ERK phosphorylation was
attenuated by 1 ) neutralizing EGFR antibodies and the EGFR kinase inhibitor, AG1478, 2 ) neutralizing HB-EGF, but not
amphiregulin , antibodies, heparin, or CM197, and 3 ) pharmacological inhibitors of matrix degrading metalloproteinases or TACE small interfering RNA
Wayne et al., Mol Endocrinol 2007
:
Lastly, the EGF-like factor
amphiregulin (AREG) activated RAS and
ERK1/2 phosphorylation in granulosa cells by mechanisms that were selectively blocked by an EGFR antagonist but not by an SFK antagonist
Noma et al., Mol Endocrinol 2011
:
Collectively, these results document that the expression of type III NRG1 is induced in granulosa cells during ovulation and that NRG1 enhances
AREG induced
ERK1/2 phosphorylation in both granulosa cells and cumulus cells