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PI3 — RHOA

Text-mined interactions from Literome

Wei et al., Am J Physiol Heart Circ Physiol 2000 : In addition, focal adhesion kinase ( FAK ) and phosphatidylinositol (PI) 3-kinase were required for full activation of the alpha-actin promoter by RhoA
Qiang et al., Blood 2004 (Multiple Myeloma...) : Analysis of endogenous signaling pathways revealed that protein kinase D/protein kinase Cmicro ( PKD/PKCmicro ) and RhoA were both activated in a phosphatidylinositol 3-kinase (PI-3K) dependent manner
Jiang et al., Mol Cell Biol 2004 (Cell Transformation, Neoplastic...) : Ectopic expression of RhoB, but not the close relative RhoA , inhibits Ras, PI3K , and Akt induction of transformation, migration, and invasion and induces apoptosis and anoikis
Da Silva et al., Nat Neurosci 2005 : PMGS induces axon specification by enhancing TrkA activity locally, which triggers phosphatidylinositol-3-kinase (PI3K)- and Rac1 dependent inhibition of RhoA signaling and the consequent actin depolymerization in one neurite only
Zubkov et al., J Cardiovasc Pharmacol 2004 : The following results were observed : ( 1 ) endothelin-1 produced phosphorylation of MAPK and RhoA and contraction by activation of endothelin-A but not endothelin-B receptors ; ( 2 ) MAPK inhibitors, PD 98059 and U0126, PTK inhibitor, genistein, Src kinase inhibitor, damnacanthal, and Janus tyrosine kinase ( JAK2 ) inhibitor, AG-490, abolished endothelin-1 induced contraction and MAPK immunoreactivity ; ( 3 ) PTK inhibitor, staurosporine, and phosphatidylinositol 3-kinase (PI- 3K) inhibitor wortmannin abolished endothelin-1 induced contraction but not MAPK immunoreactivity ; ( 4 ) Rho-kinase inhibitor, Y-27632, reduced endothelin-1 induced contraction ; ( 5 ) PI-3K inhibitor, wortmannin, but not PKC and PTK inhibitors, reduced endothelin-1 induced RhoA activation ; ( 6 ) endothelin-1 increased the level of myosin light chain ( MLC ) phosphorylation, and Rho-kinase inhibitor, Y-27632, reduced the effect of endothelin- 1 on MLC phosphorylation
Gao et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009 : [PI3-kinase mediates activity of RhoA and interaction of RhoA with mDia1 in thrombin induced platelet aggregation ]