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PTH — RUNX2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Krishnan et al., Mol Endocrinol 2003
:
Here, we investigated whether
PTH regulates the expression and/or activity of
Cbfa1 in osteoblastic cells and in a rat metatarsal organ culture assay ... To demonstrate
PTH regulation of
Cbfa1 activity, a construct containing six tandem Cbfa1 binding elements fused to luciferase was shown to be rapidly stimulated in response to PTH
van der Horst et al., J Bone Miner Res 2005
:
In addition, PTHrP and
PTH repressed
RunX2 and osx expression ... PTHrP and
PTH prevented the upregulation of
RunX2 expression associated with osteoblast differentiation in an indirect response
Wang et al., J Endocrinol Invest 2006
:
The purpose of this study was both to investigate whether
PTH regulates
Runx2 as well as osterix expression and to identify the signaling used ... Using RT-PCR, we confirmed that
PTH ( 1-34 )
regulated Runx2 and osterix mRNA expression, in rat osteoblast-like cell line UMR 106, in a dose- and time dependent manner ...
PTH in low concentrations
stimulated both
Runx2 and osterix mRNA expression while that in high concentrations did not ... These observations demonstrate that
PTH stimulates
Runx2 and osterix expression in vitro, at least in part, at transcriptional level
Komori et al., Frontiers in bioscience : a journal and virtual library 2008
:
Estrogen and
parathyroid hormone (PTH) enhance Runx2 expression and activity through anabolic effects, however, estrogen negatively
regulates Runx2 in osteoclastogenesis
Graciolli et al., Nephrol Dial Transplant 2009
(Calcinosis...) :
Phosphorus overload and
PTH induce aortic expression of
Runx2 in experimental uraemia ... However, the in vivo
effect of phosphate and
PTH on
Runx2 expression remains unknown
Sabbieti et al., J Cell Physiol 2009
:
PTH increased
Runx-2 protein expression in Fgf2+/+ but not Fgf2-/- osteoblasts ... By immunocytochemistry,
PTH treatment
induced nuclear accumulation of
Runx-2 only in Fgf2+/+ osteoblasts ...
PTH and FGF-2
regulate Runx-2 via activation of the cAMP response element binding proteins ( CREBs ) ... Silencing of FGF-2 in Fgf2+/+ osteoblasts blocked the stimulatory
effect of
PTH on
Runx-2 and CREBs phosphorylation
Selvamurugan et al., FEBS Lett 2009
:
We show here that
PTH stimulated
Runx2 phosphorylation in rat osteoblastic cells