Aisa et al., Biochim Biophys Acta 2003
:
The released form is stable at neutral and alkaline pH and, in both cell types, intracellular and extracellular cathepsin B activities are increased by interleukin-1 beta (IL-1beta) and parathyroid hormone (PTH) Aisa et al., Biochim Biophys Acta 1996
(Osteosarcoma) :
Cathepsin B activity and its regulation by interleukin 1 beta (IL-1 beta) and parathyroid hormone (PTH) was investigated in normal human osteoblast-like cells ( hOB ) and in the human osteoblastic osteosarcoma cell line MG-63 ... IL-1 beta ( 1-100 U/ml ) and PTH ( 10 ( -9 ) M-10 ( -6 ) M ) significantly stimulated cathepsin B activity in cell extracts and in conditioned media