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RAB7B — TNF

Text-mined interactions from Literome

Wang et al., Blood 2007 : Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of tumor necrosis factor (TNF)-alpha , IL-6, nitric oxide, and IFN-beta, and potentiate LPS induced activation of mitogen activated protein kinase, nuclear factor kappaB, and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4
Yao et al., J Immunol 2009 (Inflammation) : Accordingly, Rab7b can negatively regulate TLR9 triggered production of TNF-alpha , IL-6, and IFN-beta in macrophages by impairing activation of MAPKs and NF-kappaB pathways